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(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide 1 amino 1,3 cyclopentanedicarboxylic acid 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid 2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid 2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid 2 amino 4 phosphonobutyric acid 2 amino 5 phosphonovaleric acid 2 methyl 6 (2 phenylvinyl)pyridine 2 methyl 6 (phenylethynyl)pyridine 2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine 3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid 3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid 3,5 dihydroxyphenylglycine 4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone 4 amino 2 oxabicyclo3.1.0hexane 4,6 dicarboxylic acid 4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide 4 aminobutyric acid 4 phosphonophenylglycine 5-aminolevulinic acid hexyl ester 6 hydroxydopamine 6 methyl 2 (phenylethynyl)pyridine 6 methyl 2 phenylazo 3 pyridinol 6-methyl-2-(phenylethynyl)pyridine 9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide 9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide Absence epilepsy Adolescent Adult Aged Aged, 80 and over Amino Acids Analgesics, Non-Narcotic Analysis of Variance Animal Communication Animals Animals, Newborn Anthraquinones Anti-Inflammatory Agents Antibiotics Anticoagulants Anticonvulsants Antidepressive Agents, Tricyclic Aorta, Thoracic Apoptosis Arachidonic Acids Area Under Curve Article Association Learning Asthma Astrocytes August Copenhagen Irish rat Avoidance Learning BEAS-2B epithelial cells Baclofen Behavior, Animal Benzofurans Benzopyrans Benzoxazines Benzylamines Bicyclo Compounds, Heterocyclic Biological Availability Blotting, Western Brain Brain Infarction Brain Mapping Brain Neoplasms Breast Cancer CB receptors COS Cells Calcium Calixarene Calixarenes Cannabinoid Receptor Agonists Caprolactam Carbon Radioisotopes Carrier Proteins Cell Line, Tumor Cells, Cultured Central Nervous System Diseases Cercopithecus aethiops Cerebral Cortex Cerebral Infarction Chemical sympathectomy Chromatography, Liquid Chronic treatment Ciprofloxacin Circadian Rhythm Coloring Agents Connexin-43 Convulsants Corticosteroid Corticosterone Cross-Over Studies Crystal Cyclic AMP Cyclins Cycloleucine Cytosol DNA Primers Densitometry Des-Arg9-bradykinin Diabetic nephropathy Disease Models, Animal Dizocilpine Maleate Dose-Response Relationship, Drug Down-Regulation Drug Monitoring Electroencephalography Electrophysiology Encephalomyelitis, Autoimmune, Experimental Endocannabinoids Endothelin-1 Endothelium, Vascular Epilepsy Epilepsy, Absence Epithelial cells Estradiol Evans Blue Evoked Potentials Excitatory Amino Acid Antagonists Female Fluorescophanes Forelimb Forskolin Functional Laterality Fungal Proteins G protein coupled receptor GABA Agonists GABA Antagonists GABA Modulators GABA-A Receptor Antagonists GABAergic system GILZ GRM1 gene GRM2 gene Gastrointestinal Motility Gene Expression Gene Expression Regulation Genetic Glial Fibrillary Acidic Protein Glucocorticoid Glucose Glutamic Acid Half-Life Hepatitis, Toxic Hepatocytes Heterocyclic compounds Hindlimb Histamine Humans Hydrolysis I-kappa B Kinase IL-6 IL-8 Imidazoles Imitative Behavior Immunohistochemistry In Vitro Indoles Infarction, Middle Cerebral Artery Inflammation Injections, Intravenous Injections, Intraventricular Intestinal Secretions Intestine, Large Ischemia Ischemic Attack, Transient Islets of Langerhans Kainic Acid Ki-67 Antigen Kinetics Leukocytes, Mononuclear Ligands Liposomes Long-Term Potentiation MAP Kinase Signaling System MTEP Macaca Macaca mulatta Magnetic Resonance Imaging Malaria Male Mepyramine Metabolic pathway Metformin Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mice, Nude Microdialysis Microscopy, Electron Middle Aged Models, Animal Models, Molecular Molecular Molecular Targeted Therapy Morpholines Motor Activity Movement Munc18 Proteins Munc18 protein Muscarinic Muscle Contraction NF-?B NF-kappa B NHBE Naphthalenes Neoplastic Stem Cells Nerve Net Nervous System Physiology Neural Pathways Neuroglia Neuroprotective Agents NotOAChecked Nucleic Acid Synthesis Inhibitors Nursing Osteoblasts Oxazines Oxytocics PBN PET Pancreas Parkinson disease Pentylenetetrazole Perforant Pathway Perfusion Pharmacodynamic Pharmacology Phenazopyridine Phosphatidylinositol Phosphates Phosphinic Acids Photosensitizing Agents Piperidines Polyunsaturated Alkamides Postural Balance Pregnancy Prenatal Exposure Delayed Effects Proliposome Powders Psychomotor Performance Pulmonary epithelium Purkinje cell Pyrazoles Pyridines Quinolines R-SNARE Proteins RANTES RANTES, allergic encephalitis RNA, Messenger RO0711401 Rab protein Rats Rats, Inbred ACI Rats, Inbred F344 Rats, Inbred Lew Rats, Inbred Strains Rats, Mutant Strains Rats, Sprague-Dawley Rats, Wistar Rattus Reaction Time Receptor, Cannabinoid, CB1 Receptors, Adrenergic, beta Receptors, Drug Receptors, Metabotropic Glutamate Receptors, Opioid Recognition (Psychology) Reflex Reverse Transcriptase Polymerase Chain Reaction Rimonabant Saliva Seizure Seizures Severity of Illness Index Signal Transduction Smooth muscle cells Somatosensory Cortex Spike-wave discharges Spinocerebellar Ataxias Spinocerebellar Ataxias, Animals Sprague Dawley rat Stress, Psychological Supersensitivity Synapses Synapsins Synaptic Transmission T lymphocyte, Animals Tetrazolium Salts, Animalia Thalamic Nuclei Thalamus Tissue Fixation Tolerance Transactivation Transcription Up-Regulation VU0360172 WAG/Rij rats WIN55,212, Animals Western blotting Western blotting, 2-Amino-5-phosphonovalerate Western blotting, Age Factors Western blotting, Aging Western blotting, Amino Acids Western blotting, Animals Wistar albino Glaxo rat Wistar albino Glaxo rat, Animals Wistar rat, Allosteric Regulation Xanthenes absence acetylcysteine adenosine triphosphatase (potassium) adolescent adult aging agmatine algorithm alpha 1 adrenergic receptor blocking agent alpha ethylglutamate alpha methyl 4 tetrazolylphenylglycine alpha methylserine o phosphate amantadine amenamevir amide amino acid receptor blocking agent aminolevulinic acid aminolevulinic acid hexyl ester analysis of variance anandamide animal animal cell animal experiment animal model animal tissue anti-inflammatories anti-inflammatory effects antibiotics antidepressant activity antidepressant agent antiestrogen antineoplastic activity antiviral anxiety aorta area under the curve article astrocyte attention attenuation atypical antipsychotic agent autism azd 2066 basimglurant behavior benzoxazine derivative beta adrenergic receptor beta-agonists beta2-adrenoceptor agonists bioavailability blood body posture bradykinin brain brain blood vessel brain capillary brain cortex brain damage brain depth stimulation brain infarction size brain ischemia brain level brain protection brain protein brain region brain slice brain tumor calcium cell level calcium ion calcium ions calcium transport calix[4]arenes calixarene calixarenes cancer cell culture cancer graft cancer growth cancer inhibition cannabinoid 1 receptor cannabinoid 1 receptor agonist cannabinoids cannabis addiction carbon carbon 14 caregiver caudate nucleus cell culture cell death cell proliferation cellular distribution central nervous system central nervous system disease cerebellum cerebellum disease cerebrovascular accident chemical binding chemistry cinnabarinic acid clinical trial co-crystals cocaine dependence cognitive development compounds concentration response conference paper confidence interval controlled clinical trial controlled study convalescence corpus callosum corpus striatum corticosteroid crossover procedure culture medium cyclic AMP cyclin D1 cyclin D2 cytochrome P450 3A4 cytokines data analysis dentate gyrus depolarization depression desipramine detrusor dexamethasones dextro aspartic acid diabetes diabetes mellitus diabetic retinopathy dialysate diazepam diazoxide dihydroxyphenylglycine dipraglurant disease model disease severity dizocilpine dose calculation dose response dose time effect relation down regulation drug absorption drug administration route drug antagonism drug bioavailability drug blood level drug clearance drug cost drug dependence drug derivative drug design drug determination drug distribution drug dose comparison drug effect drug effects drug efficacy drug half life drug mechanism drug metabolite drug potentiation drug receptor binding drug research drug safety drug targeting drug tolerability drug-resistance dyskinesia educational intervention efaroxan electrocorticography electroencephalogram electroencephalography electromyography electron microscopy endothelin 1 endothelin 1, age endothelium cell enzyme enzyme activation enzyme activity epithelial cells erythromycin ex vivo study excitatory amino acid transporter excitatory amino acid transporter 1 exosomes extracellular vesicles facial expression female flow fluconazole food and drug administration forelimb forskolin fragile X syndrome frontal cortex fura 2 gamma rhythm gene gene deletion gene expression gene expression regulation gene inactivation gene transcription general practice genetic absence epilepsy genetic disorder genetic model genetics gesture glia cell glioblastoma glioma glioma cell glucocorticoids glutamate receptor 1 glutamate receptor 3 glutamate receptor 4 glutamate receptor antagonist glutamic acid glycine derivative glycoprotein P granule cell granulocyte/macrophage colony-stimulating factor (GM-CSF) half life time happy puppet syndrome hemichannels hexaminolevulinate c 14 high performance liquid chromatography hippocampus human human cell human experiment human-animal bond hydrocortisone hydrolysis hypothesis idazoxan imidazoline derivative imidazoline receptor imipramine immune response immunoblotting immunocytochemistry immunohistochemistry immunoreactivity in situ hybridization in vitro study in vivo study individual differences infant inflammation inhibition kinetics injection insulin insulin release interleukin 1beta interleukin 6 interleukin 8 interviews intestinal permeability intestine contraction intestine perfusion intracellular calcium intravesical drug administration ketamine knockout mouse kynurenine lactation large intestine latent period learning learning disorder leukocyte levacecarnine ligand lipopolysaccharide liquid chromatography liver cell liver injury liver necrosis liver toxicity long term depression long term potentiation mGlu5 receptor major depression male mass spectrometry mavoglurant maze test medical literature medical research melanoma memory memory disorder messenger RNA metabolism metabolite metabotropic receptor metabotropic receptor 1 metabotropic receptor 1alpha metabotropic receptor 2 metabotropic receptor 3 metabotropic receptor 3, adaptation metabotropic receptor 4 metabotropic receptor 5 metabotropic receptor 5, aged metabotropic receptor 7 metabotropic receptor 8 metabotropic receptor 8, absence metabotropic receptor agonist metabotropic receptor antagonist metabotropic receptor, absence methodology microdosing microfluorometry microvasculature midazolam middle aged, Administration, Intravesical middle cerebral artery middle cerebral artery occlusion mitochondria mitogen activated protein kinase molecular model molecular pathology molecularly targeted therapy morpholine derivative mouse movement (physiology) multiple sclerosis muscarinic mutagenesis mutant n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor stimulating agent n phenyl 7 (hydroxyimino)cyclopropabchromen 1a caboxamide n phenyl 7 (hydroxyimino)cyclopropabchromen1a carboxamide naphthalene derivative nebulization neonatal imitation, Administration, Inhalation nerve cell nerve cell network nerve cell plasticity nervous system electrophysiology neural stem cell neuroleptic agent neurologic disease neuromodulation neuroprotection neurotransmission neurotransmitter release newborn nociceptin nonhuman normal human nuclear magnetic resonance imaging nucleotide sequence nucleus accumbens nude mouse opiate receptor opioid like receptor 1 oral drug bioavailability oscillation osmotic minipump oxidative stress oxygen tension oxytocin oxytocin test p38 Mitogen-Activated Protein Kinases pancreas islet paracetamol parvalbumin passive avoidance pathogenesis pathology pathophysiology patient participation pentetrazole pentobarbital perforant nerve tract perinatal period pertussis toxin phase 2 clinical trial (topic) phentolamine phentolamine mesylate, animal tissue phosphatidylinositol 3 kinase phosphoinositide hydrolysis phospholipid phosphoserine photosensitizing agent, absence of side effects physiology piperidine derivative polyphosphoinositide polyphosphoinositide, absence polyphosphoinositide, animal experiment pomaglumetad methionil positive feedback practice guideline prenatal stress primary care priority journal priority journal, Administration, Oral priority journal, Adrenergic alpha-Antagonists pritelivir prostaglandin GH synthase protected learning time protein Homer 1a protein analysis protein expression protein function protein hydrolysis protein interaction protein localization protein protein interaction protein synthesis protein synthesis inhibition publication putamen pyrazole derivative, animal experiment pyridine derivative, allosterism qualitative research rab3A GTP-Binding Protein radiation dose radioactivity radiopharmaceutical agent rat rat strain rat strain, Analysis of Variance rat, Adrenergic Uptake Inhibitors rat, Analysis of Variance reactive oxygen metabolite receptor binding, Adaptation, Physiological receptor blocking, 1-Phosphatidylinositol 3-Kinase receptor blocking, Acetaminophen receptor down regulation receptor gene receptor intrinsic activity receptor protein receptor subtype receptor subtype, antigen presenting cell receptor upregulation recording reduction regulatory mechanism respiratory mucosa review rhein rimonabant, absence ro 0711401 ro 4419513 ro 4432717 saliva level schizophrenia scratching seizure sennoside, animal experiment sensitivity analysis sensor sensorimotor function sensorimotor integration serotonin 2A receptor signal noise ratio signal transduction signaling pathways skill smooth muscle social behavior social interaction, imitation recognition sodium chloride, absence sodium chloride, animal behavior somatosensory cortex spatial memory species comparison spike spike wave spike wave discharge spinal cord state dependent learning statistical analysis stem cell stereotactic device stimulation strain gauge transducer striate cortex symptom, Aminobutyric Acids syn 119 synapse synapse vesicle synapsin I synapsin II synaptic transmission synaptobrevin synaptophysin synaptosomal associated protein 25 synaptosome syntaxin 1 tandem mass spectrometry tandem mass spectrometry, Animals task performance tert butyl hydroperoxide, animal cell tert-Butylhydroperoxide thalamocortical tract thalamocortical tract, Animals thalamus thalamus nucleus thalamus reticular nucleus theta rhythm tissue preparation tobacco dependence tolbutamide toxicology trachea transducer, Animal triphenyltetrazolium, article tristetrapolin tubercidin umbilical artery umbilical vein unclassified drug unclassified drug, allosterism unclassified drug, animal cell unclassified drug, animal experiment unclassified drug, animal tissue vascular endothelial cells vascular endothelium vascular ring, Animals ventroposterolateral nucleus, Allosteric Regulation ventroposteromedial thalamic nucleus, Anandamide vesicular glutamate transporter 1, animal experiment volunteer vu 0360172 warfarin wild type, Animals zk 253, adult zk 253, area under the curve
Number of items at this level: 1414.

(3,4 dihydro 2h pyranol2,3 bquinolin 7yl)(cis 4 ethoxycycloexyl) methanone

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n (1 piperidyl) 1h pyrazole 3 carboxamide

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

1 amino 1,3 cyclopentanedicarboxylic acid

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl) propionic acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

2 amino 2 (2 carboxycyclopropyl) 3 (xanthen 9 yl)propionic acid

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

2 amino 3 (3,4 dichlorobenzyloxy) 6 fluorobicyclo3.1.0hexane 2,6 dicarboxylic acid

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

2 amino 4 phosphonobutyric acid

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

2 amino 5 phosphonovaleric acid

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

2 methyl 6 (2 phenylvinyl)pyridine

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

2 methyl 6 (phenylethynyl)pyridine

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo1,2,3 de1,4benzoxazine

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

3 (3, 4 dichlorobenzylamino) propyl (diethoxymethyl) phosphinic acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3 (3,4 dichlorobenzylamino)propyl(diethoxymethyl)phosphinic acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

3,5 dihydroxyphenylglycine

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

4 amino 2 oxabicyclo3.1.0hexane 4,6 dicarboxylic acid

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

4 amino 2 thiabicyclo3.1.0hexane 4,6 dicarboxylic acid 2,2 dioxide

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

4 aminobutyric acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

4 phosphonophenylglycine

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

5-aminolevulinic acid hexyl ester

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

6 hydroxydopamine

Chess-Williams, RG, Grassby, Paul, Culling, W., Penny, W., Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

6 methyl 2 (phenylethynyl)pyridine

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

6 methyl 2 phenylazo 3 pyridinol

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

6-methyl-2-(phenylethynyl)pyridine

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

9h xanthene 9 carboxylic acid(4 trifluoromethyloxazol 2 yl)amide

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

9h xanthene 9 carboxylix acid (4 trifluoromethyl oxazol 2 yl)amide

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Absence epilepsy

D'Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K, Stauffer, S.R., Nicoletti, F., van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Adolescent

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Adult

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Aged, 80 and over

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Amino Acids

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Analgesics, Non-Narcotic

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Analysis of Variance

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Animal Communication

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Animals

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Animals, Newborn

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Anthraquinones

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Anti-Inflammatory Agents

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Antibiotics

Gruber, T. (2015) On the way to new shores: caprolactam derivatives as starting point for unprecedented antibiotics. In: Hungarian-German Spring symposium on organic (and) structural chemistry, April 2015, Budapest (Hungary).

Anticoagulants

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Anticonvulsants

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Antidepressive Agents, Tricyclic

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Aorta, Thoracic

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Apoptosis

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Arachidonic Acids

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Area Under Curve

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Article

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Association Learning

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Asthma

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Astrocytes

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

August Copenhagen Irish rat

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Avoidance Learning

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

BEAS-2B epithelial cells

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Baclofen

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Behavior, Animal

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Benzofurans

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Benzopyrans

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Benzoxazines

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Benzylamines

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Bicyclo Compounds, Heterocyclic

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Biological Availability

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Blotting, Western

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Brain

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Brain Infarction

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Brain Mapping

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Brain Neoplasms

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Breast Cancer

Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M. and Harris, Adrian L. (2018) Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism, 28 (5). 679-688.e4. ISSN 1550-4131

CB receptors

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

COS Cells

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Calcium

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Calixarene

Bombicz, P., Gruber, Tobias, Weber, E. and Kálmán, A. (2009) Supramolecular morphotropy of calixarene inclusion compounds. In: 12th International Seminar on Inclusion Compounds, 4-9 April 2009, Stellenbosch (South Africa).

Calixarenes

Bombicz, P., Gruber, Tobias, Fischer, C. and Weber, E. (2012) Tailor made calixarenes. In: Indaba 7 Workshop – Insights from Structure, 2012, Skukuza (South Africa).

Eißmann, F., Kaltofen, J., Gruber, Tobias and Weber, E. (2006) Fluorogenic calix[6]- and calix[8]¬arenes – Synthesis and conformational behaviour. In: Symposium ChemoChips, 15-16 November 2006, Weimar (Germany).

Cannabinoid Receptor Agonists

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Caprolactam

Gruber, T. (2015) On the way to new shores: caprolactam derivatives as starting point for unprecedented antibiotics. In: Hungarian-German Spring symposium on organic (and) structural chemistry, April 2015, Budapest (Hungary).

Carbon Radioisotopes

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Carrier Proteins

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Cell Line, Tumor

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cells, Cultured

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Central Nervous System Diseases

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Cercopithecus aethiops

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Cerebral Cortex

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Cerebral Infarction

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Chemical sympathectomy

Chess-Williams, RG, Grassby, Paul, Culling, W., Penny, W., Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

Chromatography, Liquid

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Chronic treatment

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Ciprofloxacin

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Circadian Rhythm

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Coloring Agents

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Connexin-43

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

Convulsants

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Corticosteroid

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Corticosterone

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Cross-Over Studies

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Crystal

Gruber, T. (2014) Little change, deep impact: solvents and their fundamental influence on crystal formation. In: 65th BHT: Crystallography in Practice, June 2014, Freiberg (Germany).

Cyclic AMP

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Cyclins

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Cycloleucine

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Cytosol

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

DNA Primers

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Densitometry

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Des-Arg9-bradykinin

Marsh, Katrina A. and Hill, Stephen J. (1994) Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. British Journal of Pharmacology, 112 (3). pp. 934-938. ISSN 0007-1188

Diabetic nephropathy

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

Disease Models, Animal

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Dizocilpine Maleate

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Dose-Response Relationship, Drug

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Down-Regulation

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Drug Monitoring

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Electroencephalography

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Electrophysiology

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Encephalomyelitis, Autoimmune, Experimental

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Endocannabinoids

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Endothelin-1

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Endothelium, Vascular

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Epilepsy

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Epilepsy, Absence

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Epithelial cells

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Rider, Christopher F., King, Elizabeth M., Holden, Neil S., Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Estradiol

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Evans Blue

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Evoked Potentials

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Excitatory Amino Acid Antagonists

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Female

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Fluorescophanes

Gruber, Tobias (2015) Fluorescophanes: a new generation of fluorescent macrocycles. In: Calix2015, 5-9 July 2015, Giardini Naxos (Italy).

Forelimb

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Forskolin

HAWTHORN, M. H., CHESSWILLIAMS, R. G., Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

Functional Laterality

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Fungal Proteins

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

G protein coupled receptor

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

GABA Agonists

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

GABA Antagonists

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

GABA Modulators

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

GABA-A Receptor Antagonists

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

GABAergic system

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

GILZ

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

GRM1 gene

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

GRM2 gene

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Gastrointestinal Motility

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Gene Expression

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Gene Expression Regulation

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Genetic

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Glial Fibrillary Acidic Protein

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Glucocorticoid

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F., King, Elizabeth M., Holden, Neil S., Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

Glucose

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Glutamic Acid

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Half-Life

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Hepatitis, Toxic

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Hepatocytes

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Heterocyclic compounds

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Hindlimb

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Histamine

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Humans

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Hydrolysis

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

I-kappa B Kinase

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

IL-6

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

IL-8

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Imidazoles

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Imitative Behavior

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Immunohistochemistry

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

In Vitro

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Indoles

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Infarction, Middle Cerebral Artery

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Inflammation

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Injections, Intravenous

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Injections, Intraventricular

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Intestinal Secretions

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Intestine, Large

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Ischemia

Kuroda, Satoshi, Katsura, Ken-ichiro, Hillered, Lars, Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

Ischemic Attack, Transient

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Islets of Langerhans

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Kainic Acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Ki-67 Antigen

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Kinetics

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Leukocytes, Mononuclear

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Ligands

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Liposomes

Ahmed, Waqar, Khan, Iftikhar, Yousaf, Sakib, Subramanian, Sneha, Albed Alhnan, Mohamed and Elhissi, Abdelbary (2018) Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid. AAPS PharmSciTech . ISSN 1530-9932

Long-Term Potentiation

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

MAP Kinase Signaling System

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

MTEP

D'Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K, Stauffer, S.R., Nicoletti, F., van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

Macaca

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Macaca mulatta

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Magnetic Resonance Imaging

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Malaria

Gruber, Tobias (2013) Without malaria no gin & tonic (with experiments). In: Christmas Lecture 2013, December 2013, University of Freiberg (Germany).

Male

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Mepyramine

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

Metabolic pathway

Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M. and Harris, Adrian L. (2018) Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism, 28 (5). 679-688.e4. ISSN 1550-4131

Metformin

Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M. and Harris, Adrian L. (2018) Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism, 28 (5). 679-688.e4. ISSN 1550-4131

Mice

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Mice, Inbred C57BL

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Mice, Inbred Strains

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Mice, Knockout

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Mice, Nude

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Microdialysis

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Microscopy, Electron

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Middle Aged

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Models, Animal

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Models, Molecular

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Molecular

Gruber, T. (2015) In the molecular cage: complexation of biologically active compounds. In: Invited Lecture hosted by the Institute of Pharmacology and Toxicology, January 2015, University of the German Armed Forces, Munich.

Molecular Targeted Therapy

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Morpholines

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Motor Activity

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Movement

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Munc18 Proteins

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Munc18 protein

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Muscarinic

Marsh, K. A., Harriss, D. R. and Hill, S. J. (1996) Desensitization of muscarinic receptor-coupled inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. The Journal of Urology, 155 (4). pp. 1439-1443. ISSN 0022-5347

Muscle Contraction

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

NF-?B

Holden, Neil S., Gong, W., King, E. M., Kaur, M., Giembycz, M. A. and Newton, R. (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. British journal of pharmacology, 152 (6). pp. 891-902. ISSN 0007-1188

NF-kappa B

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

King, Elizabeth M., Kaur, Manminder, Gong, Wei, Rider, Christopher F., Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

NHBE

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Naphthalenes

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Neoplastic Stem Cells

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nerve Net

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nervous System Physiology

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Neural Pathways

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Neuroglia

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Neuroprotective Agents

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

NotOAChecked

Biswas, Subhajit, Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Nucleic Acid Synthesis Inhibitors

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Nursing

Ashelford, Sarah, Raynsford, Justine and Taylor, Vanessa (2016) Pathophysiology and pharmacology for nursing students. SAGE publishing. ISBN 9781473906600

Osteoblasts

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Oxazines

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Oxytocics

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

PBN

Kuroda, Satoshi, Katsura, Ken-ichiro, Hillered, Lars, Bates, Timothy E. and Siesjö, Bo K. (1996) Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiology of Disease, 3 (2). pp. 149-157. ISSN 0969-9961

PET

Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M. and Harris, Adrian L. (2018) Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism, 28 (5). 679-688.e4. ISSN 1550-4131

Pancreas

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Parkinson disease

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Pentylenetetrazole

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Perforant Pathway

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Perfusion

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Pharmacodynamic

Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M. and Harris, Adrian L. (2018) Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer. Cell Metabolism, 28 (5). 679-688.e4. ISSN 1550-4131

Pharmacology

Ashelford, Sarah, Raynsford, Justine and Taylor, Vanessa (2016) Pathophysiology and pharmacology for nursing students. SAGE publishing. ISBN 9781473906600

Phenazopyridine

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Phosphatidylinositol Phosphates

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Phosphinic Acids

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Photosensitizing Agents

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Piperidines

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Polyunsaturated Alkamides

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Postural Balance

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pregnancy

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Prenatal Exposure Delayed Effects

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Proliposome Powders

Ahmed, Waqar, Khan, Iftikhar, Yousaf, Sakib, Subramanian, Sneha, Albed Alhnan, Mohamed and Elhissi, Abdelbary (2018) Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid. AAPS PharmSciTech . ISSN 1530-9932

Psychomotor Performance

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Pulmonary epithelium

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

Purkinje cell

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Pyrazoles

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Pyridines

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Quinolines

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

R-SNARE Proteins

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

RANTES

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

RANTES, allergic encephalitis

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

RNA, Messenger

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

RO0711401

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Rab protein

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Rats

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred ACI

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Inbred F344

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Rats, Inbred Lew

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Rats, Inbred Strains

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Rats, Mutant Strains

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Rats, Sprague-Dawley

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rats, Wistar

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Rattus

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Reaction Time

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Receptor, Cannabinoid, CB1

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Receptors, Adrenergic, beta

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Receptors, Drug

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Receptors, Metabotropic Glutamate

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Receptors, Opioid

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Recognition (Psychology)

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Reflex

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Reverse Transcriptase Polymerase Chain Reaction

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Rimonabant

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Saliva

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Seizure

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Seizures

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Severity of Illness Index

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Signal Transduction

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Smooth muscle cells

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

Somatosensory Cortex

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Spike-wave discharges

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Spinocerebellar Ataxias

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Spinocerebellar Ataxias, Animals

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Sprague Dawley rat

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Stress, Psychological

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Supersensitivity

HAWTHORN, M. H., CHESSWILLIAMS, R. G., Grassby, P. F. and BROADLEY, K. J. (1985) The use of forskolin to investigate the site of cardiac beta-adrenoreceptor supersensitivity. Journal of Autonomic Pharmacology, 5 (3). pp. 231-239. ISSN 0144-1795

Synapses

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Synapsins

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Synaptic Transmission

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

T lymphocyte, Animals

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Tetrazolium Salts, Animalia

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Thalamic Nuclei

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Thalamus

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Tissue Fixation

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Tolerance

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

Transactivation

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Transcription

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Up-Regulation

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

VU0360172

D'Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K, Stauffer, S.R., Nicoletti, F., van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

WAG/Rij rats

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

D'Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K, Stauffer, S.R., Nicoletti, F., van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

D'Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C. M., Vieira, E., Stauffer, S.R., Conn, P. J., Bosco, P., Nicoletti, F., van Luijtelaar, G. and Ngomba, R. T. (2014) Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology, 85 . pp. 91-103. ISSN 0028-3908

WIN55,212, Animals

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Western blotting

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Western blotting, 2-Amino-5-phosphonovalerate

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Western blotting, Age Factors

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Western blotting, Aging

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Western blotting, Amino Acids

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Western blotting, Animals

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Wistar albino Glaxo rat

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

Wistar albino Glaxo rat, Animals

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Wistar rat, Allosteric Regulation

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Xanthenes

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

absence

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

acetylcysteine

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

adenosine triphosphatase (potassium)

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

adolescent

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

adult

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

aging

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

agmatine

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

algorithm

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

alpha 1 adrenergic receptor blocking agent

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

alpha ethylglutamate

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

alpha methyl 4 tetrazolylphenylglycine

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

alpha methylserine o phosphate

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

amantadine

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

amenamevir

Biswas, Subhajit, Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

amide

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

amino acid receptor blocking agent

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

aminolevulinic acid

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

aminolevulinic acid hexyl ester

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

analysis of variance

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

anandamide

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

animal

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal cell

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

animal experiment

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

animal model

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

animal tissue

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

anti-inflammatories

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

anti-inflammatory effects

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

antibiotics

Gruber, T. (2011) Sensor active molecules and antibiotics. In: Invited Lecture, January 2011, Hungarian Academy of Science, Budapest (Hungary),.

antidepressant activity

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

antidepressant agent

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

antiestrogen

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

antineoplastic activity

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

antiviral

Biswas, Subhajit, Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

anxiety

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

aorta

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

area under the curve

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

article

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

astrocyte

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

attention

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

attenuation

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

atypical antipsychotic agent

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

autism

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

azd 2066

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

basimglurant

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

behavior

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

benzoxazine derivative

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

beta adrenergic receptor

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

beta-agonists

Chess-Williams, RG, Grassby, Paul, Culling, W., Penny, W., Broadley, K. J. and Sheridan, D. J. (1985) Cardiac postjunctional supersensitivity to β-agonists after chronic chemical sympathectomy with 6-hydroxydopamine. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 (2). pp. 162-166. ISSN 0028-1298

beta2-adrenoceptor agonists

Holden, Neil S., Rider, C. F., Bell, M. J., Velayudhan, J., King, E. M., Kaur, M., Salmon, M., Giembycz, M. A. and Newton, R. (2010) Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action. British journal of pharmacology, 160 (2). pp. 410-420. ISSN 0007-1188

Rider, Christopher F., King, Elizabeth M., Holden, Neil S., Giembycz, Mark A. and Newton, Robert (2011) Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. Journal of Pharmacology and Experimental Therapeutics, 338 (3). pp. 860-869. ISSN 0022-3565

bioavailability

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

blood

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

body posture

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

bradykinin

Marsh, Katrina A. and Hill, Stephen J. (1992) Bradykinin B2 receptor-mediated phosphoinositide hydrolysis in bovine cultured tracheal smooth muscle cells. British Journal of Pharmacology, 107 (2). pp. 443-447. ISSN 0007-1188

Marsh, Katrina A. and Hill, Stephen J. (1993) Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells. British Journal of Pharmacology, 110 (1). pp. 29-35. ISSN 0007-1188

Marsh, Katrina A. and Hill, Stephen J. (1994) Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. British Journal of Pharmacology, 112 (3). pp. 934-938. ISSN 0007-1188

brain

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

brain blood vessel

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

brain capillary

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

brain cortex

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain damage

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

brain depth stimulation

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

brain infarction size

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain ischemia

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

brain level

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

brain protection

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

brain protein

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

brain region

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

brain slice

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

brain tumor

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

calcium cell level

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium ion

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calcium ions

Marsh, Katrina A. and Hill, Stephen J. (1993) Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells. British Journal of Pharmacology, 110 (1). pp. 29-35. ISSN 0007-1188

calcium transport

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

calix[4]arenes

Schulze, M., Gruber, Tobias, Weber, E., Pollex, R. and Mazik, M. (2014) Design, synthesis and complexation studies of new indium ligands: calix[4]arenes as ligands. In: Akita Summer Camp, 2014, Holzhau (Germany).

calixarene

Bombicz, P., Csöregh, I., Gruber, Tobias, Weber, E. and Kálmán, A. (2006) Isostructurality of co-crystals of an ester substituted dinitro calixarene host. In: ECM23, 23rd European Crystallographic Meeting, 6-11 August 2006, Leuven (Belgium).

calixarenes

Gruber, T. (2005) Synthesis, structures and inclusion behaviour of functionalized calixarenes. In: ., October 2005, Department of Natural Sciences, University of Chemnitz (Germany).

cancer cell culture

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer graft

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer growth

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cancer inhibition

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cannabinoid 1 receptor

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

cannabinoid 1 receptor agonist

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

cannabinoids

Bakshi, Hamid A, Faruck, Hakkim L, Ravesh, Zeinab, Ansari, Prawej, Hannan, J M A, Hashimoto, Rina, Takayama, Kazuo, Farzand, Rabia, Nasef, Mohamed M, Mensah, Adelaide, Aljabali, Alaa A A, Mishra, Vijay, Charbe, Nitin B, Goyal, Rohit, Negi, Poonam, Serrano-Aroca, Ángel, Bahar, Bojlul, El-Tanani, Mohamed, Courtenay, Aaron J, McCarron, Paul, Jack, Iain G and Tambuwala, Murtaza (2022) Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation. Integrative cancer therapies, 21 . p. 15347354221096766. ISSN 1534-7354

cannabis addiction

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

carbon

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

carbon 14

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

caregiver

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

caudate nucleus

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

cell culture

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

cell death

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

cell proliferation

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cellular distribution

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

central nervous system

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

central nervous system disease

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebellum

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

cerebellum disease

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cerebrovascular accident

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

chemical binding

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

chemistry

Gruber, Tobias (2014) The chemistry of X-mas. In: JCF Christmas Lecture, December 2014, University of Cologne (Germany).

cinnabarinic acid

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

clinical trial

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

co-crystals

Bombicz, P., Csöregh, I., Gruber, Tobias, Weber, E. and Kálmán, A. (2006) Isostructurality of co-crystals of an ester substituted dinitro calixarene host. In: ECM23, 23rd European Crystallographic Meeting, 6-11 August 2006, Leuven (Belgium).

cocaine dependence

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

cognitive development

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

compounds

Gruber, T. (2015) In the molecular cage: complexation of biologically active compounds. In: Invited Lecture hosted by the Institute of Pharmacology and Toxicology, January 2015, University of the German Armed Forces, Munich.

concentration response

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

conference paper

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

confidence interval

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

controlled clinical trial

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

controlled study

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

convalescence

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

corpus callosum

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

corpus striatum

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

corticosteroid

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

crossover procedure

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

culture medium

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

cyclic AMP

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

cyclin D1

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cyclin D2

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

cytochrome P450 3A4

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

cytokines

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

data analysis

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

dentate gyrus

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

depolarization

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

depression

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

desipramine

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

detrusor

Harriss, D. R., Marsh, K. A., Birmingham, A. T. and Hill, S. J. (1995) Expression of muscarinic M sub 3 -receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. The Journal of Urology, 154 (3). pp. 1241-1245. ISSN 0022-5347

Marsh, K. A., Harriss, D. R. and Hill, S. J. (1996) Desensitization of muscarinic receptor-coupled inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. The Journal of Urology, 155 (4). pp. 1439-1443. ISSN 0022-5347

dexamethasones

King, Elizabeth M., Kaur, Manminder, Gong, Wei, Rider, Christopher F., Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

dextro aspartic acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

diabetes

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

diabetes mellitus

Siriwardena, A. Niroshan, Middlemass, Jo B., Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

diabetic retinopathy

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

dialysate

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

diazepam

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

diazoxide

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

dihydroxyphenylglycine

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

dipraglurant

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

disease model

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

disease severity

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

dizocilpine

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

dose calculation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

dose response

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

dose time effect relation

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

down regulation

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

drug absorption

Carobolante, Greta, Mantaj, Julia, Ferrari, Enrico and Vllasaliu, Driton (2020) Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery. Pharmaceutics, 12 (3). p. 226. ISSN 1999-4923

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug administration route

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug antagonism

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

drug bioavailability

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug blood level

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug clearance

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

drug cost

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dependence

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug derivative

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug design

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug determination

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

drug distribution

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug dose comparison

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effect

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug effects

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug efficacy

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug half life

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug mechanism

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

drug metabolite

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

drug potentiation

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

drug receptor binding

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

drug research

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug safety

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

drug targeting

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug tolerability

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

drug-resistance

Biswas, Subhajit, Sukla, Soumi and Field, Hugh J. (2014) Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections. Future Medicinal Chemistry, 6 (1). pp. 45-55. ISSN 1756-8919

dyskinesia

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

educational intervention

Siriwardena, A. Niroshan, Middlemass, Jo B., Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

efaroxan

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

electrocorticography

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

electroencephalogram

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

electroencephalography

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

electromyography

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

electron microscopy

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

endothelin 1

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S.G., Kortenska, L.V., Mitreva, R.G., Pashova, V.D., Ngomba, R.T. and Nicoletti, F. (2007) Multimodal assessment of neuroprotection applied to the use of MK-801 in the endothelin-1 model of transient focal brain ischemia. Brain Research, 1153 (1). pp. 58-67. ISSN 0006-8993

endothelin 1, age

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

endothelium cell

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

enzyme

Gruber, T. (2010) From enzyme mimics to sensor molecules. In: ., June 2010, Hungarian Academy of Science, Budapest (Hungary.

enzyme activation

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

enzyme activity

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

epithelial cells

Kelly, M. M., King, E. M., Rider, C. F., Gwozd, C., Holden, Neil S., Eddleston, J., Zuraw, B., Leigh, R., O'Byrne, P. M. and Newton, R. (2012) Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide. British Journal of Pharmacology, 165 (6). pp. 1737-1747. ISSN 0007-1188

erythromycin

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

ex vivo study

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

excitatory amino acid transporter

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

excitatory amino acid transporter 1

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

exosomes

Carobolante, Greta, Mantaj, Julia, Ferrari, Enrico and Vllasaliu, Driton (2020) Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery. Pharmaceutics, 12 (3). p. 226. ISSN 1999-4923

extracellular vesicles

Carobolante, Greta, Mantaj, Julia, Ferrari, Enrico and Vllasaliu, Driton (2020) Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery. Pharmaceutics, 12 (3). p. 226. ISSN 1999-4923

facial expression

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

female

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

flow

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

fluconazole

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

food and drug administration

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

forelimb

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

forskolin

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

fragile X syndrome

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

frontal cortex

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

fura 2

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

gamma rhythm

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

gene

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

gene deletion

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

gene expression

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

gene expression regulation

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

King, Elizabeth M., Kaur, Manminder, Gong, Wei, Rider, Christopher F., Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

gene inactivation

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

gene transcription

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

general practice

Siriwardena, A. Niroshan, Middlemass, Jo B., Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

genetic absence epilepsy

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic disorder

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetic model

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

genetics

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

gesture

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

glia cell

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

glioblastoma

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glioma

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glioma cell

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glucocorticoids

Chivers, Joanna E., Gong, Wei, King, Elizabeth M., Seybold, Joachim, Mak, Judith C., Donnelly, Louise E., Holden, Neil S. and Newton, Robert (2006) Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids. Molecular pharmacology, 70 (6). pp. 2084-2095. ISSN 0026-895X

Newton, Robert and Holden, Neil S. (2007) Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor? Molecular pharmacology, 72 (4). pp. 799-809. ISSN 0026-895X

glutamate receptor 1

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor 3

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor 4

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

glutamate receptor antagonist

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

glutamic acid

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

glycine derivative

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

glycoprotein P

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

granule cell

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

granulocyte/macrophage colony-stimulating factor (GM-CSF)

Catley, Matthew C., Chivers, Joanna E., Holden, Neil S., Barnes, Peter J. and Newton, Robert (2005) Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. British journal of pharmacology, 145 (1). pp. 114-22. ISSN 0007-1188

half life time

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

happy puppet syndrome

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

hemichannels

Cliff, Chelsy L, Williams, Bethany, Chadjichristos, Christos E, Mouritzen, Ulrik, Squires, Paul E and Hills, Claire E (2022) Connexin 43: A target for the treatment of inflammation in secondary complications of the kidney and eye in diabetes. International Journal of Molecular Sciences, 23 (600). ISSN 1422-0067

hexaminolevulinate c 14

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

high performance liquid chromatography

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

hippocampus

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

human

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

human cell

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Nicoletti, F., Battaglia, G., Storto, M., Ngomba, Richard T., Iacovelli, L., Arcella, A., Gradini, R., Sale, P., Rampello, L., De Vita, T., Di Marco, R., Melchiorri, D. and Bruno, V. (2007) Metabotropic glutamate receptors: Beyond the regulation of synaptic transmission. Psychoneuroendocrinology, 32 (Supp 1). S40-S45. ISSN 0306-4530

human experiment

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

human-animal bond

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

hydrocortisone

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

hydrolysis

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

hypothesis

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

idazoxan

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline derivative

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imidazoline receptor

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

imipramine

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

immune response

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

immunoblotting

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

immunocytochemistry

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

immunohistochemistry

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

immunoreactivity

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

in situ hybridization

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

in vitro study

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

in vivo study

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

individual differences

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

infant

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

inflammation

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

inhibition kinetics

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

injection

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

insulin

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

insulin release

Shepherd, R. M., Hashmi, M. N., Kane, C., Squires, Paul and Dunne, M. J. (1996) Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: Implications for stimulus-response coupling of insulin release. British Journal of Pharmacology, 119 (5). pp. 911-916. ISSN 0007-1188

interleukin 1beta

King, Elizabeth M., Kaur, Manminder, Gong, Wei, Rider, Christopher F., Holden, Neil S. and Newton, Robert (2009) Regulation of tristetraprolin expression by interleukin-1β and dexamethasone in human pulmonary epithelial cells: Roles for nuclear factor-κB and p38 mitogen-activated protein kinase. The journal of pharmacology and experimental therapeutics, 330 (2). pp. 575-585. ISSN 0022-3565

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 6

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interleukin 8

Newton, Robert, Holden, Neil S., Catley, Matthew C., Oyelusi, Wale, Leigh, Richard, Proud, David and Barnes, Peter J. (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IκB kinase inhibitors. The journal of pharmacology and experimental therapeutics, 321 (2). pp. 734-42. ISSN 0022-3565

interviews

Siriwardena, A. Niroshan, Middlemass, Jo B., Ward, Kate and Wilkinson, Carol (2009) Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners. BMC Medical Education, 8 (4). pp. 1-9. ISSN 1472-6920

intestinal permeability

Carobolante, Greta, Mantaj, Julia, Ferrari, Enrico and Vllasaliu, Driton (2020) Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery. Pharmaceutics, 12 (3). p. 226. ISSN 1999-4923

intestine contraction

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intestine perfusion

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

intracellular calcium

Marsh, Katrina A. and Hill, Stephen J. (1994) Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. British Journal of Pharmacology, 112 (3). pp. 934-938. ISSN 0007-1188

intravesical drug administration

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

ketamine

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

knockout mouse

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

kynurenine

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

lactation

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

large intestine

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

latent period

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

learning

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

learning disorder

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

leukocyte

Besong, Gilbert, Battaglia, Giuseppe, D'Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard T., Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L., Nicoletti, Ferdinando R., Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria and Nicoletti, Ferdinando (2002) Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. Journal of Neuroscience, 22 (13). pp. 5403-5411. ISSN 0270-6474

levacecarnine

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

ligand

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

Ngomba, Richard Teke, Santolini, I., Salt, T. E., Ferraguti, F., Battaglia, G., Nicoletti, F. and Van Luijtelaar, G. (2011) Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy. Epilepsia, 52 (7). pp. 1211-1222. ISSN 0013-9580

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

lipopolysaccharide

Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R.a, Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F. and Goudet, C. (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology, 81 (5). pp. 643-656. ISSN 0026-895X

liquid chromatography

Lappin, Graham and Garner, R. Colin (2006) A review of human phase 0 (microdosing) clinical trials following the US food and drug administration exploratory investigational new drug studies guidance. International Journal of Pharmaceutical Medicine, 20 (3). pp. 159-165. ISSN 1364-9027

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

liver cell

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver injury

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver necrosis

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

liver toxicity

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

long term depression

Nicoletti, F., Bruno, V., Ngomba, R. T, Gradini, R. and Battaglia, G. (2015) Metabotropic glutamate receptors as drug targets: what's new? Current Opinion in Pharmacology, 20 . pp. 89-94. ISSN 14714892

long term potentiation

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

mGlu5 receptor

D'Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K, Stauffer, S.R., Nicoletti, F., van Luijtelaar, G. and Ngomba, R.T. (2013) Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology, 66 . pp. 330-338. ISSN 0028-3908

major depression

Matrisciano, F., Scaccianoce, S., Del Bianco, P., Panaccione, I., Canudas, A. M., Battaglia, G., Riozzi, B., Ngomba, R. T., Molinaro, G., Tatarelli, R., Melchiorri, D. and Nicoletti, F. (2005) Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. Journal of Neurochemistry, 93 (5). pp. 1345-1352. ISSN 0022-3042

male

Arcella, A., Carpinelli, G., Battaglia, G., D'Onofrio, M., Santoro, F., Ngomba, R. T., Bruno, V., Casolini, P., Giangaspero, F. and Nicoletti, F. (2005) Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo. Neuro-Oncology, 7 (3). pp. 236-245. ISSN 1522-8517

Bikbaev, A., Neyman, S., Ngomba, Richard, Conn, J., Nicoletti, F. and Manahan-Vaughan, D. (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3 (5). ISSN 1932-6203

Cinque, C., Zuena, A .R., Casolini, P., Ngomba, Richard T., Melchiorri, D., Maccari, S., Nicoletti, F., Di Giorgi Gerevini, V. and Catalani, A. (2003) Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Neuroscience, 122 (1). pp. 277-284. ISSN 0306-4522

Citraro, R., Russo, E., Ngomba, R.T., Nicoletti, F., Scicchitano, F., Whalley, B.J., Calignano, A. and De Sarro, G. (2013) CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations. Epilepsy Research, 106 (1-2). pp. 74-82. ISSN 0920-1211

Granata, Filippo, Potenza, Rossella Luisa, Fiori, Anna, Strom, Roberto, Caronti, Brunella, Molinari, Paola, Donsante, Sonia, Citro, Gennaro, Iacovelli, Luisa, De Blasi, Antonio, Ngomba, Richard T., Palladini, Guido and Passarelli, Francesca (2003) Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium. European Journal of Pharmacology, 482 (1-3). pp. 17-23. ISSN 0014-2999

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460. ISSN 0091-2700

Lappin, Graham, Kuhnz, Wilhelm, Jochemsen, Roeline, Kneer, Johannes, Chaudhary, Ajai, Oosterhuis, Berend, Drijfhout, Willem Jan, Rowland, Malcolm and Garner, R. Colin (2006) Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs. Clinical Pharmacology and Therapeutics, 80 (3). pp. 203-215. ISSN 0009-9236

Manahan-Vaughan, D., Ngomba, Richard T., Storto, M., Kulla, A., Catania, M. V., Chiechio, S., Rampello, L., Passarelli, F., Capece, A., Reymann, K. G. and Nicoletti, F. (2003) An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats. Neuropharmacology, 44 (1). pp. 17-25. ISSN 0028-3908

Marrocco, J., Mairesse, J., Ngomba, R.T., Silletti, V., Van Camp, G., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S. and Morley-Fletcher, S. (2012) Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 32 (48). pp. 17143-17154. ISSN 0270-6474

Matrisciano, F., Storto, M., Ngomba, Richard T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D. and Nicoletti, F. (2002) Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology, 42 (8). pp. 1008-1015. ISSN 0028-3908

Moyanova, S. G., Mastroiacovo, F., Kortenska, L. V., Mitreva, R. G., Fardone, E., Santolini, I., Sobrado, M., Battaglia, G., Bruno, V., Nicoletti, F. and Ngomba, R. T. (2011) Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 31 (4). pp. 1107-1118. ISSN 0271-678X

Moyanova, S. G., Mitreva, R. G., Kortenska, L. V., Nicoletti, F. and Ngomba, R.T. (2013) Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke. Experimental and Translational Stroke Medicine, 5 (1). ISSN 2040-7378

Ngomba, R. T., Biagioni, F., Casciato, S., Willems-Van Bree, E., Battaglia, G., Bruno, V., Nicoletti, F. and Van Luijtelaar, E. L. J. M. (2005) The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 49 (SUPPL.). pp. 89-103. ISSN 0028-3908

Ngomba, R. T., Santolini, I., Biagioni, F., Molinaro, G., Simonyi, A., Van Rijn, C. M., D'Amore, V., Mastroiacovo, F., Olivieri, G., Gradini, R., Ferraguti, F., Battaglia, G., Bruno, V., Puliti, A., Van Luijtelaar, G. and Nicoletti, F. (2011) Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. Neuropharmacology, 60 (7-8). pp. 1281-1291. ISSN 0028-3908

Ngomba, Richard T., Ferraguti, F., Badura, A., Citraro, R., Santolini, I., Battaglia, G., Bruno, V., De Sarro, G., Simonyi, A., van Luijtelaar, G. and Nicoletti, F. (2008) Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures. Neuropharmacology, 54 (2). pp. 344-354. ISSN 0028-3908

Rumsey, R. D. E., Squires, Paul and Read, N. W. (1993) In vitro effects of sennoside on contractile activity and fluid flow in the perfused large intestine of the rat. Pharmacology, 47 (SUP 1). pp. 32-39. ISSN 0031-7012

Simonyi, Agnes, Ngomba, Richard T., Storto, Marianna, Catania, Maria V., Miller, Laura A., Youngs, Brian, DiGorgi-Gerevini, Valeria, Nicoletti, Ferdinando and Sun, Grace Y. (2005) Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Research, 1043 (1-2). pp. 95-106. ISSN 0006-8993

Simpson, E.A., Sclafani, Valentina, Paukner, A., Hamel, A.F., Novak, M.A., Meyer, J.S., Suomi, S.J. and Ferrari, P.F. (2014) Inhaled oxytocin increases positive social behaviors in newborn macaques. Proceedings of the National Academy of Sciences, 111 (19). pp. 6922-6927. ISSN 0027-8424

Storto, Marianna, Ngomba, Richard T., Battaglia, Giuseppe, Freitas, Isabel, Griffini, Patrizia, Richelmi, Plinio, Nicoletti, Ferdinando and Vairetti, Mariapia (2003) Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. Journal of Hepatology, 38 (2). pp. 179-187. ISSN 0168-8278

Van Rijn, C. M., Gaetani, S., Santolini, I., Badura, A., Gabova, A., Fu, J., Watanabe, M., Cuomo, V., Van Luijtelaar, G., Nicoletti, F. and Ngomba, R. T. (2010) WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia, 51 (8). pp. 1511-1521. ISSN 0013-9580

mass spectrometry

Klem, B., Lappin, Graham, Nicholson, S., Van De Wetering, J., De Vries, D. E., Oosterhuis, B. and Garner, R. C. (2006) Determination of the bioavailability of 14C-hexaminolevulinate using accelerator mass spectrometry after intravesical administration to human volunteers. Journal of Clinical Pharmacology, 46 (4). pp. 456-460.