Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma

Arsenovic, N., Senyszyn, Steph, Naik, V. , Reed, M. and Moreira, R. (2009) Trichilemmal cyst with carcinoma in situ within an atypical fibroxanthoma. American Journal of Dermatopathology, 31 (6). pp. 587-590. ISSN 0193-1091

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A 91-year-old lady presented with an 8-month history of a slow growing keratotic nodule on the forehead, which was excised. Histological examination showed a well-defined lesion with marked cellular pleomorphism. Numerous mitoses were present. The cells stained positively with CD10 and CD68 and weakly with smooth muscle actin. However, the tumor was negative for cytokeratins (AE1/AE3), epithelial membrane antigen (EMA), S100, Melan A, HMB45, leukocyte common antigen (LCA), desmin, and CD31. Therefore, the lesion was designated as atypical fibroxanthoma (AFX) by exclusion. Within the AFX, there was also a cyst lined by squamous epithelium showing pilar keratinization. The epithelium showed full-thickness dysplasia with increased mitotic activity and was stained positively with AE1/AE3, thus supporting our view of carcinoma in situ within the wall of the cyst. To the best of our knowledge, this article describes the first case of trichilemmal cyst with carcinoma in situ arising within an AFX. © 2009 Lippincott Williams & Wilkins, Inc.

Keywords:CD31 antigen, CD45 antigen, CD68 antigen, common acute lymphoblastic leukemia antigen, cytokeratin AE1, cytokeratin AE3, desmin, epithelial membrane antigen, melan A, monoclonal antibody HMB 45, protein S 100, smooth muscle actin, aged, article, cancer diagnosis, carcinoma in situ, case report, differential diagnosis, dysplasia, female, fibroxanthoma, forehead, genetic polymorphism, histology, human, human tissue, keratinization, keratosis, mitosis, priority journal, sebaceous cyst, skin nodule, skin tumor, squamous epithelium, Aged, 80 and over, Epidermal Cyst, Histiocytoma, Benign Fibrous, Humans, Immunohistochemistry, Neoplasms, Multiple Primary, Skin Diseases, Skin Neoplasms, Tumor Markers, Biological
Subjects:B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > School of Health & Social Care
ID Code:9924
Deposited On:30 Jul 2013 13:21

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