Aloysius, Mark M., Mc Kechnie, Alastair J., Robins, Richard A. , Verma, Chandan, Eremin, Jennifer M., Farzaneh, Farzin, Habib, Nagy A, Bhalla, Joti, Hardwick, Nicola R., Satthaporn, Sukchai, Sreenivasan, Thiagarajan, El-Sheemy, Mohammed and Eremin, Oleg (2009) Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs. Journal of Translational Medicine, 7 (1). p. 18. ISSN 1479-5876
Full content URL: http://dx.doi.org/10.1186/1479-5876-7-18
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| Item Type: | Article |
|---|---|
| Item Status: | Live Archive |
Abstract
Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-specific T cell responses elicited by vaccination with class I alone or both class I and II epitope (p766 and p672)-pulsed DCs, prepared without IFN-α, (iii) association between circulating T regulatory cells (Tregs) and clinical responses.
| Keywords: | Immunotherapy, Cancer immunotherapy |
|---|---|
| Subjects: | B Subjects allied to Medicine > B100 Anatomy, Physiology and Pathology |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 9797 |
| Deposited On: | 10 Jun 2013 09:00 |
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