Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants

Kunutsor, Setor Kwadzo, Apekey, Tanefa Antoinette and Steur, Marinka (2013) Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. European Journal of Epidemiology, 28 (3). pp. 205-221. ISSN 0393-2990

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The evidence on the association between baseline vitamin D status and risk of incident hypertension in general populations is limited and has not been reliably quantified. We conducted a systematic review and meta-analysis of published prospective studies evaluating the associations of baseline vitamin D status (circulating 25-hydroxyvitamin D 25(OH)D levels and dietary vitamin D intake) with risk of hypertension. Eligible studies were identified in a literature search of MEDLINE, EMBASE, and Web of Science up to November 2012. Pooled relative risks (RRs) with 95 % confidence intervals were calculated using random effects models. Generalized least-squares trend estimation was used to assess dose-response relationships. Of the 2,432 articles reviewed for eligibility, eight unique prospective cohorts with aggregate data on 283,537 non-overlapping participants and 55,816 incident hypertension cases were included. The RRs (95 % CIs) for hypertension in a comparison of extreme thirds of baseline levels of vitamin D were 0.70 (0.58, 0.86) for seven studies that measured blood 25(OH) D levels and 1.00 (0.95, 1.05) for four studies that assessed dietary vitamin D intake. The pooled RR of incident hypertension per 10 ng/mL increment in baseline 25(OH)D levels was 0.88 (0.81, 0.97) in dose-response analysis. Evidence was lacking of heterogeneity among studies that measured blood 25(OH) D levels and those that assessed dietary vitamin D status. Studies are needed to determine whether the association of vitamin D with hypertension represents a causal association and also to determine whether vitamin D therapy may be beneficial in the prevention or the treatment of hypertension. © 2013 Springer Science+Business Media Dordrecht.

Keywords:Vitamins, Vitamin D
Subjects:B Subjects allied to Medicine > B190 Anatomy, Physiology and Pathology not elsewhere classified
Divisions:College of Social Science > School of Health & Social Care
ID Code:9607
Deposited On:22 May 2013 12:58

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