Herpesvirus latency and therapy--from a veterinary perspective

Field, Hugh J., Biswas, Subhajit and Mohammad, Islam T. (2006) Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Research, 71 (2-3). pp. 127-133. ISSN 0166-3542

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This short review considers how the human herpesviruses were among the first viruses to be effectively treated by means of antiviral therapy although the ability of alphaherpsviruses to establish neuronal latency with reactivation remains the major obstacle to achieving a cure. Laboratory animals played an essential role in the development of herpes antivirals including our understanding of the complexity of the neurological infection in relation to chemotherapy. The existence of natural herpesvirus infections in domestic species also contributes to our understanding of latency and reactivation relevant to antiviral therapy although the use of antivirals to treat or prevent virus infections in veterinary species has been minimal, to date. The review briefly focuses on herpes infections in the horse and cat where some progress has already been achieved in the veterinary antiviral field.

Additional Information:Dedicated to Prof. Erik De Clercq on the occasion of reaching the status of Emeritus-Professor at the Katholieke Universiteit Leuven in September 2006
Keywords:Virology, Veterinary Antivirals, DNA Virus
Subjects:C Biological Sciences > C540 Virology
B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
C Biological Sciences > C520 Medical and Veterinary Microbiology
Divisions:College of Science > School of Life Sciences
ID Code:9375
Deposited On:10 May 2013 10:05

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