Biswas, S., Sanyal, A., Hemadri, D. , Tosh, C., Mohapatra, J. K., Kumar, R. Manoj and Bandyopadhyay, S. K. (2006) Sequence analysis of the non-structural 3A and 3C protein-coding regions of foot-and-mouth disease virus serotype Asia1 field isolates from an endemic country. Veterinary Microbiology, 116 (1-3). pp. 187-193. ISSN 0378-1135
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
A total of 18 foot-and-mouth disease virus (FMDV) serotype Asia1 field isolates belonging to two different lineages (including the divergent group) as delineated earlier in VP1-based phylogeny were sequenced in the non-structural 3A and 3C protein-coding regions. The phylogenetic trees representing the regions coding for the non-structural proteins were very similar to that of the structural VP1 protein-coding region. Phylogenetic comparison at 3C region revealed clustering of Asia1 viruses with the isolates of serotypes O, A and C in the previously identified clade. Comparison of amino acid sequences identified lineage-specific signature residues in both the non-structural proteins. Overall analysis of the amino acid substitutions revealed that the 3A coding region was more prone to amino acid alterations than 3C region.
| Keywords: | Virology, veterinary medicine, Animal Diseases, Microbiology, RNA virus, Molecular phylogenetics |
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| Subjects: | C Biological Sciences > C520 Medical and Veterinary Microbiology C Biological Sciences > C440 Molecular Genetics |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 9373 |
| Deposited On: | 10 May 2013 10:13 |
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