Lloyd-Jones, Gareth, Osborn, A. Mark, Ritchie, Donald A. , Strike, Peter, Hobman, Jon L., Brown, Nigel L. and Rouch, Duncan A. (1994) Accumulation and intracellular fate of tellurite in tellurite-resistant Escherichia coli: a model for the mechanism of resistance. FEMS Microbiology Letters, 118 (1-2). pp. 113-119. ISSN 0378-1097
Full content URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb06812...
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
The tellurite accumulation properties of three Escherichia coli strains containing different tellurium-resistance determinants of Gram-negative origin, from plasmids pMER610, pHH1508a and RK2, were compared. In all three cases membrane-associated tellurium crystallization was observed, and neither reduced uptake nor increased export contributed to the resistance. Specific membrane-proximal reduction is proposed as the mechanism of resistance to tellurite coded by all three determinants, despite their lack of sequence homology.
| Keywords: | tellurite, unclassified drug, article, drug resistance, escherichia coli, nonhuman, priority journal, toxicity, Crystallization, Drug Resistance, Microbial, Models, Biological, Oxidation-Reduction, Plasmids, Support, Non-U.S. Gov't, Tellurium |
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| Subjects: | C Biological Sciences > C180 Ecology C Biological Sciences > C500 Microbiology |
| Divisions: | College of Science > School of Life Sciences |
| Related URLs: | |
| ID Code: | 8978 |
| Deposited On: | 06 May 2013 19:16 |
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