Crystal chemistry and solvent effects in polymorphic systems: Sulfathiazole

Blagden, Nicholas, Davey, R. J., Lieberman, H. F. , Williams, L., Payne, R., Roberts, R., Rowe, R. and Docherty, R. (1998) Crystal chemistry and solvent effects in polymorphic systems: Sulfathiazole. Journal of the Chemical Society - Faraday Transactions, 94 (8). pp. 1035-1044. ISSN 0956-5000

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Sulfathiazole, a compound that forms four known crystal structures, has been examined with a view to understanding its polymorphism. A graph set approach was used to classify the structural differences and similarities of the polymorphs, the results of which indicated packing motifs common to three of the four structures. By combining this analysis with experimental morphological data, it has been possible to examine the origins of the observed solvent dependence of polymorph appearance in this system. In particular, the possible link between the observed hydrogen-bond motifs of each form and the associated processes of nucleation and crystal growth from n-propanol, nitromethane, ethanol, water and ammonia solution, have been considered.

Additional Information:cited By (since 1996) 84
Keywords:crystal chemistry, solvent effects, polymorphs, Sulfathiazole
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Pharmacy
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ID Code:8782
Deposited On:03 Apr 2013 15:51

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