Crystal engineering of polymorph appearance: the case of sulphathiazole

Blagden, Nicholas (2001) Crystal engineering of polymorph appearance: the case of sulphathiazole. Powder Technology, 121 (1). pp. 46-52. ISSN 0032-5910

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A combined modeling and experimental strategy has been applied to the problem of solvents and reaction byproducts influence on the appearance of sulphathiazole polymorphs from solution. In terms of developing a robust process for isolating polymorphs, a purely structural approach is limited since it neglects the role kinetics have in determining the appearance of polymorph structures. Ostwald recognized this (in 1899) when detailing his Rule of Stages. As does the lack of polymorph selectivity and the phenomena of disappearing polymorphs further highlight the issue of kinetics. Using the Polymorph Appearance Strategy (Scheme 1) our current work (Faraday Trans. 94(8) (1998) 1035; J. Pharm. 172 (1998) 169; Chem. Br. (1999) 44) aims to address some of these issues. © 2001 Elsevier Science B.V. All rights reserved.

Keywords:Byproducts, Crystals, Sulfur compounds, Polymorphs, Powders, solvent, sulfathiazole, crystal, solvent, chemical engineering, chemical reaction, conference paper, crystal structure, crystallization, kinetics, molecular model
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
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ID Code:8776
Deposited On:08 Jul 2013 12:39

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