DynAMITe: A prototype large area CMOS APS for breast cancer diagnosis using x-ray diffraction measurements

Konstantinidis, A., Anaxagoras, Thalis, Esposito, Michela , Allinson, Nigel and Speller, R. (2012) DynAMITe: A prototype large area CMOS APS for breast cancer diagnosis using x-ray diffraction measurements. In: Medical Imaging 2012: Physics of Medical Imaging, 5-8 February 2012, San Diego, California.

Full content URL: http://dx.doi.org/10.1117/12.911541

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Item Type:Conference or Workshop contribution (Paper)
Item Status:Live Archive


X-ray diffraction studies are used to identify specific materials. Several laboratory-based x-ray diffraction studies were made for breast cancer diagnosis. Ideally a large area, low noise, linear and wide dynamic range digital x-ray detector is required to perform x-ray diffraction measurements. Recently, digital detectors based on Complementary Metal-Oxide- Semiconductor (CMOS) Active Pixel Sensor (APS) technology have been used in x-ray diffraction studies. Two APS detectors, namely Vanilla and Large Area Sensor (LAS), were developed by the Multidimensional Integrated Intelligent Imaging (MI-3) consortium to cover a range of scientific applications including x-ray diffraction. The MI-3 Plus consortium developed a novel large area APS, named as Dynamically Adjustable Medical Imaging Technology (DynAMITe), to combine the key characteristics of Vanilla and LAS with a number of extra features. The active area (12.8 � 13.1 cm 2) of DynaMITe offers the ability of angle dispersive x-ray diffraction (ADXRD). The current study demonstrates the feasibility of using DynaMITe for breast cancer diagnosis by identifying six breast-equivalent plastics. Further work will be done to optimize the system in order to perform ADXRD for identification of suspicious areas of breast tissue following a conventional mammogram taken with the same sensor. © 2012 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Keywords:Active area, Active Pixel Sensor, Breast biopsies, Breast cancer diagnosis, Breast tissues, CMOS APS, Digital detector, Digital x-ray detector, Intelligent imaging, Key characteristics, Large area sensors, Low noise, Medical imaging technology, Metal-oxide, Scientific applications, Specific materials, Wide dynamic range, X-ray diffraction measurements, X-ray diffraction studies, Diseases, Mammography, Medical imaging, Sensors, Tissue, X ray diffraction
Subjects:F Physical Sciences > F350 Medical Physics
Divisions:College of Science > School of Life Sciences
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ID Code:8531
Deposited On:03 Apr 2013 21:27

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