Big physics, small doses: the use of AMS and PET in human microdosing of development drugs

Lappin, Graham and Garner, R. Colin (2003) Big physics, small doses: the use of AMS and PET in human microdosing of development drugs. Nature Reviews Drug Discovery, 2 (3). pp. 233-240. ISSN 1474-1776

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The process of early clinical drug development has changed little over the past 20 years despite an up to 40 failure rate associated with inappropriate drug metabolism and pharmacokinetics of candidate molecules. A new method of obtaining human metabolism data known as microdosing has been developed which will permit smarter candidate selection by taking investigational drugs into humans earlier. Microdosing depends on the availability of two ultrasensitive 'big-physics' techniques: positron emission tomography (PET) can provide pharmacodynamic information, whereas accelerator mass spectrometry (AMS) provides pharmacokinetic information. Microdosing allows safer human studies as well as reducing the use of animals in preclinical toxicology.

Keywords:alpha 1A adrenergic receptor, alpha adrenergic receptor blocking agent, carbon 11, carbon 14, fluorodeoxyglucose f 18, n (2 dimethylaminoethyl) 4 acridinecarboxamide, new drug, drug, allometry, article, computer model, cost, drug absorption, drug distribution, drug excretion, drug industry, drug metabolism, drug research, genomics, human, mass spectrometry, molecule, nonhuman, positron emission tomography, priority journal, proteomics, toxicology, animal, computer assisted emission tomography, drug design, drug screening, magnetic and electromagnetic equipment, metabolism, pharmacokinetics, review, Animals, Drug Evaluation, Preclinical, Humans, Particle Accelerators, Pharmaceutical Preparations, Tomography, Emission-Computed
Divisions:College of Science > School of Pharmacy
ID Code:8244
Deposited On:23 Mar 2013 13:43

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