Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry

Lappin, Graham and Garner, R. Colin (2004) Current perspectives of 14C-isotope measurement in biomedical accelerator mass spectrometry. Analytical and Bioanalytical Chemistry, 378 (2). pp. 356-364. ISSN 1618-2642

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Accelerator mass spectrometry (AMS) is an extremely sensitive nuclear physics technique developed in the mid-70's for radiocarbon dating of historical artefacts. The technique centres round the use of a tandem Van de Graaff accelerator to generate the potential energy to permit separation of elemental isotopes at the single atom level. AMS was first used in the early 90's for the analysis of biological samples containing enriched 14C for toxicology and cancer research. Since that time biomedical AMS has been used in the study of (1) metabolism of xenobiotics in animals and humans (2) pathways of drug metabolism (3) biomarkers (4) metabolism of endogenous molecules including vitamins (5) DNA and protein binding studies and (6) clinical diagnosis. A new drug development concept which relies on the ultrasensitivity of AMS known as human microdosing (Phase 0) is being used to obtain early human metabolism information of candidate drugs arising out of discovery. These various aspects of AMS are reviewed in this article and a perspective on future applications of AMS provided. © Springer-Verlag 2004.

Additional Information:cited By (since 1996) 48
Keywords:Biomarkers, DNA, Drug products, Isotopes, Mass spectrometry, Medical applications, Metabolism, Nuclear physics, Proteins, Toxicity, Tumors, Van de Graaff accelerators, Accelerator mass spectrometry, Microdosing, Phase 0, Ultrasensitive drug analysis, Carbon, Animalia
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
C Biological Sciences > C720 Biological Chemistry
F Physical Sciences > F370 Nuclear and Particle Physics
Divisions:College of Science > School of Pharmacy
ID Code:8239
Deposited On:27 Mar 2013 15:23

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