Electrochemical reduction of carbamazepine in ethanol and water solutions using a glassy carbon electrode

Atkins, S., Gonzalez-Rodriguez, Jose, Sevilla, J. M. , Blazquez, M., Pineda, T. and Jimenez-Perez, Rebeca (2013) Electrochemical reduction of carbamazepine in ethanol and water solutions using a glassy carbon electrode. International Journal of Electrochemical Science, 8 (2). pp. 2056-2068. ISSN 1452-3981

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The electrochemical reduction of carbamazepine in ethanol and water using a glassy carbon electrode has been studied. In all experimental conditions of scan rate and concentration of carbamazepine an irreversible cathodic wave was observed by cyclic voltammetry (CV). Electrochemical parameters and a plausible EqC mechanism have been reported from the electrochemical measurements and digital simulation. The values of thermodynamic E1/2 were correlated with solvent polarity parameters that it can be interesting for biological, pharmaceutical and forensic purposes. Limits of Detection (LOD) for DPV are 1.1 and 9.0 g/mL (4.65x10-6 and 3.81x10-5 M) in ethanol and water, respectively. The precision and recoveries obtained for tablets and plasma samples showed that the method could be successfully used for analysis.

Keywords:Carbamazepine, electrochemical reduction, cyclic voltammetry, differential pulse voltammetry, glassy carbon electrode
Subjects:F Physical Sciences > F170 Physical Chemistry
F Physical Sciences > F100 Chemistry
F Physical Sciences > F410 Forensic Science
F Physical Sciences > F180 Analytical Chemistry
Divisions:College of Science > School of Life Sciences
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ID Code:7540
Deposited On:17 Feb 2013 18:20

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