Sharma, Pallavi and Moses, John E. (2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and click linker. Org. Lett., 12 (12). pp. 2860-2863. ISSN 1523-7060
Full content URL: http://pubs.acs.org/doi/pdf/10.1021/ol100968t
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| Item Type: | Article |
|---|---|
| Item Status: | Live Archive |
Abstract
A new silyl-based reagent has been developed for “catch and release” immobilization, combining click chemistry with silyl protection. The
traditional “all carbon” attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group
linker.
| Keywords: | Click reaction, Solid phase, alkyne silane |
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| Subjects: | F Physical Sciences > F160 Organic Chemistry |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 7109 |
| Deposited On: | 17 Dec 2012 21:24 |
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