Spiteri, Christian, Sharma, Pallavi, Zhang, Fengzhi , Macdonald, Simon J. F., Keeling, Steve and Moses, John E. (2010) An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications, 46 (8). pp. 1272-1274. ISSN 1359-7345
Full content URL: http://pubs.rsc.org/en/content/articlelanding/2010...
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
An efficient synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reaction partners mediated by TBAF. Reactions are complete within 30 s, giving the target products in good to excellent yield.
| Keywords: | Bezisoxazole, benzyne, 1, 3-dipolar addition |
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| Subjects: | F Physical Sciences > F160 Organic Chemistry |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 7107 |
| Deposited On: | 21 Dec 2012 12:25 |
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