Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

Powell, Kimberley J., Sharma, Pallavi, Richens, Joanna L. , Daviss, Benjamin M., Moses, John E. and O'Shea, Paul (2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076

Full content URL: http://dx.doi.org/10.1039/C2CP42920A

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Interaction studies of mollusk derived y-Pyrone Natutral Product with phospholipid vesicles
Interaction studies of mollusk derived y-Pyrone Natutral Product with phospholipid vesicles
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Abstract

The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.

Additional Information:The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
Keywords:Polyketide
Subjects:F Physical Sciences > F160 Organic Chemistry
Divisions:College of Science > School of Life Sciences
ID Code:7101
Deposited On:26 Dec 2012 20:17

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