Powell, Kimberley J., Sharma, Pallavi, Richens, Joanna L. , Daviss, Benjamin M., Moses, John E. and O'Shea, Paul (2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076
Full content URL: http://dx.doi.org/10.1039/C2CP42920A
| Documents |
| ||||||
![[img]](http://eprints.lincoln.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
Pallavi_JACS_2009.pdf - Whole Document Restricted to Repository staff only 1MB |
| Item Type: | Article |
|---|---|
| Item Status: | Live Archive |
Abstract
The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
| Additional Information: | The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed. |
|---|---|
| Keywords: | Polyketide |
| Subjects: | F Physical Sciences > F160 Organic Chemistry |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 7101 |
| Deposited On: | 26 Dec 2012 20:17 |
Repository Staff Only: item control page