Biswas, Subhajit and Field, Hugh J. (2011) Helicase–primase inhibitors: a new approach to combat herpes simplex virus and varicella zoster virus. In: Antiviral Drug Strategies. Methods and Principles in Medicinal Chemistry . Wiley-VCH Verlag GmbH & Co. KGaA, pp. 129-146. ISBN 9783527635955, 9783527326969
Full content URL: http://onlinelibrary.wiley.com/doi/10.1002/9783527...
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| Item Type: | Book Section |
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| Item Status: | Live Archive |
Abstract
This chapter (no. 6) contains sections titled:
1. Introduction
2. The Role of Helicase Primase in the Replication of HSV
3. Selective Inhibitors of Helicase Primase as Antiherpesvirus Antivirals
4. HPIs are Effective in Cell Culture and In Vivo
5. Effects of HPIs on the Establishment and Reactivation from Latency
6. HPIs: The Biochemical Basis for the Proposed Mechanism of Action
7. HSV Acquired Resistance to HPIs
8. Patterns of Cross-Resistance
9. Further Insight into Mode of HPI Interaction with the HSV HP Complex from the Study of Resistance Mutations
10. The Frequency and Origin of HPI-Resistance Mutations
11. UL5 Lys356Asn: a Mutation Conferring High Resistance to HPI
12. The Origin of Resistance Mutations at High Frequency
13. Conclusions
14. References
| Keywords: | cross-resistance, HPI-resistant mutants, latent infection, nucleoside analogues, plaque reduction assay, Helicase primase complex |
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| Subjects: | C Biological Sciences > C540 Virology C Biological Sciences > C520 Medical and Veterinary Microbiology A Medicine and Dentistry > A300 Clinical Medicine F Physical Sciences > F151 Pharmaceutical Chemistry |
| Divisions: | College of Science > School of Life Sciences |
| Related URLs: | |
| ID Code: | 6963 |
| Deposited On: | 26 Nov 2012 17:53 |
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