Goddard, Alan and Watts, Anthony (2012) Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biology, 10 (27). ISSN 1741-7007
Full content URL: http://dx.doi.org/10.1186/1741-7007-10-27
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
| Additional Information: | Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors. |
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| Keywords: | GPCR, Palmitoylation, Cholesterol |
| Subjects: | C Biological Sciences > C700 Molecular Biology, Biophysics and Biochemistry |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 6846 |
| Deposited On: | 16 Nov 2012 12:07 |
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