PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications

Casettari, Luca, Vllasaliu, Driton, Castagnino, Enzo , Stolnik, Snjezana, Howdle, Steven and Illum, Lisbeth (2012) PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications. Progress in Polymer Science, 37 (5). pp. 659-685. ISSN 0079-6700

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Item Type:Article
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This review sets out to describe and discuss the synthetic approaches and the fields of application of PEGylated chitosan copolymers especially for medical use. The PEGylation of chitosan and chitosan derivatives is able to add new physicochemical properties to the cationic polysaccharide polymers, thereby overcoming some limitations, especially regarding their solubility and their use in drug and gene delivery (DNA and siRNA). All methods of derivatization have been considered and described together with the different methods of characterization of the copolymers. The capacities of PEGylated chitosan to reduce chitosan toxicity, to enhance membrane permeation and to form thermosensitive hydrogels have also been discussed.

Keywords:Absorption enhancement, Chitosan, Drug delivery, Gene delivery, PEG-g-chitosan, PEGylation
Subjects:B Subjects allied to Medicine > B200 Pharmacology, Toxicology and Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:6818
Deposited On:14 Nov 2012 21:24

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