Chitinase inhibition by chitobiose and chitotriose thiazolines

Macdonald, James M., Tarling, Chris A., Taylor, Edward J. , Dennis, Rebecca J., Myers, David S., Knapp, Spencer, Davies, Gideon J. and Withers, Stephen G. (2010) Chitinase inhibition by chitobiose and chitotriose thiazolines. Angewandte Chemie, 49 (14). pp. 2599-2602. ISSN 0044-8249

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A good imitation: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based mode of inhibition, make this analogue a promising candidate for broad-spectrum chitinase inhibition.

Keywords:carbohydrates;enzyme inhibitors;fungicides;insecticides;thiazolines
Subjects:C Biological Sciences > C790 Molecular Biology, Biophysics and Biochemistry not elsewhere classified
Divisions:College of Science > School of Life Sciences
ID Code:6121
Deposited On:07 Sep 2012 21:14

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