Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

Chansaisakorn, Winai, Sriphavatsarakom, Prarom, Sopakdittapong, Pisit , Trisiriroj, Monkon, Pondeenana, Somchai and Buranakarl, Chollada (2009) Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs. Veterinary Research Communications, 33 (1). pp. 67-75. ISSN 0165-7380

Full content URL: http://link.springer.com/article/10.1007/s11259-00...

[img] PDF
5966.pdf - Whole Document
Restricted to Repository staff only

Item Type:Article
Item Status:Live Archive


Oxidative stress parameters; thiobarbituric acid reaction substances (RBC-TBARS), catalase (RBC-CAT) and reduced glutathione (RBC-GSH)) and the intraerythrocytic concentrations of electrolytes; sodium and potassium (RBC-Na and RBC-K) were determined in 18 well- controlled (WC) and 22 poorly-controlled diabetic mellitus (DM). Dogs with DM had significant higher blood glucose concentration (P < 0.001), haemoglobin A1c (P < 0.01) and fructosamine (P < 0.001) compared to normal healthy dogs (n = 19). Diabetic dogs in both groups had higher RBC-CAT (P < 0.05) while RBC-TBARS were higher significantly only in poorly-controlled DM group (P < 0.05). The RBC-K was significantly higher in both DM groups (P < 0.001). No changes in RBC-GSH and RBC-Na were found between DM and control healthy dogs. By linear regression analysis, the relationship were found between degree of diabetic mellitus and RBC-CAT, RBC-TBARS, RBC-Na and RBC-K. The relationship was also found between oxidative stress parameters and intraerythrocytic K+. The results suggest that in diabetic dogs, oxidative stress occurs which related to the severity of disease and may affect potassium homeostasis.

Keywords:Oxidative stress, Intraerythrocytic sodium and potassium, Diabetic dogs
Subjects:C Biological Sciences > C742 Veterinary Biochemistry
Divisions:College of Science > School of Life Sciences
ID Code:5966
Deposited On:19 Aug 2014 08:50

Repository Staff Only: item control page