Editorial: Impact of genome instability on human health

Ray, Swagat, Chakrabarty, Sanjiban and Chaudhuri, Arnab Ray (2023) Editorial: Impact of genome instability on human health. Frontiers in Molecular Biosciences, 10 . ISSN 2296-889X

Full content URL: https://doi.org/10.3389/fmolb.2023.1243968

Editorial: Impact of genome instability on human health
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Genomic instability, characterized by alterations in DNA structure and function, has emerged as a crucial factor influencing human health and disease. In recent years, a growing body of research has focused on unraveling the intricate relationship between genomic instability and its impact on various conditions such as cancer, aging, and genetic disorders, which are reviewed here (Abugable et al., 2019; Tiwari and Wilson, 2019; Nelson and Dizdaroglu, 2020; Yousefzadeh et al., 2021). This editorial presents a synthesis of four recently published articles in Frontiers in Molecular Biosciences that delve into the mechanisms and consequences of genomic instability in different contexts. These studies underscore the role of homologous recombination deficiency in epithelial ovarian cancer, the modulation of a transcription factor in the pathogenesis of breast cancer, the epigenetic landscape of Klinefelter syndrome, and the immunomodulatory effect of PARP inhibitors (PARPi) against cancer. Together, these findings contribute to our understanding of genomic instability and pave the way for improved diagnostics, targeted therapies, and interventions to improve human health.

Keywords:DNA damage, PARP inhibition (PARPi), genomic instability, cancer, transcription factor
Subjects:C Biological Sciences > C130 Cell Biology
Divisions:COLLEGE OF HEALTH AND SCIENCE > School of Life and Environmental Sciences > Department of Life Sciences
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ID Code:55915
Deposited On:31 Aug 2023 11:45

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