Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy

Yu, Subin, Jang, Dohyub, Yuan, Hong , Huang, Wen-Tse, Kim, Minju, Marques Mota, Filipe, Liu, Ru-Shi, Lee, Hyukjin, Kim, Sehoon and Kim, Dong Ha (2021) Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy. ACS Applied Materials & Interfaces, 13 (49). pp. 58422-58433. ISSN 1944-8244

Full content URL: https://doi.org/10.1021/acsami.1c21949

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Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy
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Abstract

Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV–vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO2@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO2) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO2 and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO2, generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO2 (77.3%) and UCNP@aTiO2 (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO2@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agents, providing a valuable addition to light-triggered cancer treatments in deep tissue.

Keywords:upconversion, localized surface plasmon resonance, titanium dioxide, photosensitizer, phototherapy
Subjects:F Physical Sciences > F200 Materials Science
F Physical Sciences > F110 Applied Chemistry
C Biological Sciences > C741 Medical Biochemistry
Divisions:College of Science > School of Chemistry
ID Code:53638
Deposited On:21 Mar 2023 11:58

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