Ibrahim, Bakry, Mady, Omar Y., Tambuwala, Murtaza M. and Haggag, Yusuf A. (2022) pH-sensitive nanoparticles containing 5-fluorouracil and leucovorin as an improved anti-cancer option for colon cancer. Nanomedicine (London, England), 17 (6). pp. 367-381. ISSN 1743-5889
Full content URL: https://doi.org/10.2217/nnm-2021-0423
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nnm-2021-0423.pdf - Whole Document Available under License Creative Commons Attribution 4.0 International. 10MB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Parenteral administration of chemotherapeutic drugs, 5-fluorouracil (5-FU) and leucovorin (LV), is commonly used to treat large bowel carcinomas such as colon cancer (CC) and colorectal carcinoma (CRC). Our study aims to design a novel nanoparticulate drug-delivery vehicle for oral use capable of colon-specific release. A modified double-emulsion solvent evaporation method was used in the preparation of pH-responsive Eudargit S100 polymeric nanoparticles, loaded with 5-FU/LV combination (5-FU/LV-loaded Eudargit S100 NPs). Our optimized drug-loaded NP showed a pH-responsive drug release and exhibited significantly more cytotoxic actions in cancer-cell lines than free drugs. These findings open the way for conducting clinical trials for colon malignancies treated with nanoparticles.
| Keywords: | colon targeting, Drug delivery |
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| Subjects: | A Medicine and Dentistry > A100 Pre-clinical Medicine |
| Divisions: | College of Science > Lincoln Medical School |
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| ID Code: | 53283 |
| Deposited On: | 10 Feb 2023 09:59 |
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