Canevari, Laura, Console, Antonella, Tendi, E. A. , Clark, J. B. and Bates, Timothy (1999) Effect of postischaemic hypothermia on the mitochondrial damage induced by ischaemia and reperfusion in the gerbil. Brain research, 817 (1-2). pp. 241-245. ISSN 0006-8993
Full content URL: http://dx.doi.org/10.1016/S0006-8993(98)01278-5
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| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
In order to test the effect of hypothermia on mitochondrial function damage following cerebral ischaemia/reperfusion, Mongolian gerbils were submitted to 30 min bilateral carotid occlusion and 2 h of reperfusion at 37 degreesC or 30 degreesC. After normothermic (37 degreesC) ischaemia/reperfusion, significant decreases in mitochondrial state 3 (+ADP) oxygen consumption (-42.2%), complex II-III activity in synaptosomes (-31.7%) and complex IV were measured, in both free mitochondria and synaptosomes (-30.3% and -27. 8% respectively). However, following hypothermic (30 degreesC) reperfusion, both respiration rates and all enzyme activities remained at levels not significantly different from those in the sham operated controls.
| Additional Information: | In order to test the effect of hypothermia on mitochondrial function damage following cerebral ischaemia/reperfusion, Mongolian gerbils were submitted to 30 min bilateral carotid occlusion and 2 h of reperfusion at 37 degreesC or 30 degreesC. After normothermic (37 degreesC) ischaemia/reperfusion, significant decreases in mitochondrial state 3 (+ADP) oxygen consumption (-42.2%), complex II-III activity in synaptosomes (-31.7%) and complex IV were measured, in both free mitochondria and synaptosomes (-30.3% and -27. 8% respectively). However, following hypothermic (30 degreesC) reperfusion, both respiration rates and all enzyme activities remained at levels not significantly different from those in the sham operated controls. |
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| Keywords: | Hypothermia, Gerbil, cerebral ischemia, cerebroprotection |
| Subjects: | A Medicine and Dentistry > A100 Pre-clinical Medicine B Subjects allied to Medicine > B131 Cellular Pathology B Subjects allied to Medicine > B120 Physiology |
| Divisions: | College of Science > School of Life Sciences |
| ID Code: | 5305 |
| Deposited On: | 16 Apr 2013 15:41 |
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