Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids

Dobson, Luca and Pattison, Graham (2016) Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids. Chemical Communications, 52 (74). pp. 11116-11119. ISSN 1359-7345

Full content URL: https://doi.org/10.1039/C6CC05775F

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Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids
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Abstract

The Rh-catalyzed arylation of fluorinated ketones with boronic acids is reported. This efficient process allows access to fluorinated alcohols in high yields under mild conditions. Competition experiments suggest that difluoromethyl ketones are more reactive than trifluoromethyl ketones in this process, despite their decreased electronic activation, an effect we postulate to be steric in origin.

Keywords:fluorination, boronic acid, rhodium, ketones
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:52245
Deposited On:31 Oct 2022 14:24

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