Pattison, Graham (2018) Methods for the Synthesis of α,α-Difluoroketones. European Journal of Organic Chemistry, 2018 (27-28). pp. 3520-3540. ISSN 1434-193X
Full content URL: https://doi.org/10.1002/ejoc.201800532
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Item Type: | Article |
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Item Status: | Live Archive |
Abstract
This review describes the key methods for the synthesis of α,α-difluoroketones. These compounds are key synthetic building blocks, as well as being used as enzyme inhibitors. Effective methods for their synthesis include direct fluorination approaches and the use of pre-difluorinated building blocks, including cross-coupling and radical reactions.
Keywords: | fluorination, carbonyl derivative, Medicinal chemistry |
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Subjects: | F Physical Sciences > F100 Chemistry |
Divisions: | College of Science > School of Chemistry |
ID Code: | 52241 |
Deposited On: | 31 Oct 2022 14:55 |
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