Evaluating Follow-up and Complexity In Cancer Clinical Trials (EFACCT): A Mixed Methods Grounded Theory Study

Markham-Jones, Helene, Nelson, David, Curtis, Ffion and Law, Graham (2022) Evaluating Follow-up and Complexity In Cancer Clinical Trials (EFACCT): A Mixed Methods Grounded Theory Study. In: IPOS 2022, 29th August - 1st September, Toronto, Canada.

Evaluating Follow-up and Complexity In Cancer Clinical Trials (EFACCT): A Mixed Methods Grounded Theory Study

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Objectives/purpose: The Evaluating Follow-up and Complexity in cancer Clinical Trials (EFACCT) study aimed to understand the nature of cancer clinical trial operational delivery, evaluating challenges and burdens of professionals and patients participating in cancer research studies. The study sought to develop a contextualised grounded theory elucidating situated challenges and complexity experienced at NHS sites in the UK.

Methods: The research used a mixed methods–grounded theory (MM-GT) design. The comprehensive, contextual evaluation combined evidence from quantitative and qualitative paradigms, using inductive and deductive methods. The study drew together multifaceted perspectives and values of 165 participants from six studies; Delphi, questionnaire, and interview studies, separated into patient and professional cohorts.

Results: The data generated new knowledge on the perceptions and experiences of key NHS stakeholders, leading to the conception of a Prismatic Coherence Model (PCM), a model evaluating and interrogating features of patient care, management and follow-up in complex network and transactional pathways existing within healthcare and clinical research delivery environments. PCM is an inclusive and responsive strategic approach, sensitive to context which embraces system complexity and transdisciplinarity, in order to advance opportunities for maximising population health.

Conclusion and clinical implications: The findings have the potential to support future research models, strategic planning, trial implementation and evaluation alongside the provision of system-based designs capable of supporting transdisciplinary approaches to advancing clinical cancer research and improving patient-centred outcomes.

Keywords:Neoplasms. Tumors. Oncology (including Cancer), cancer survivorship, living with cancer, Clinical Trials, Mixed methods, Complexity, Patient Follow-up
Subjects:B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
A Medicine and Dentistry > A900 Others in Medicine and Dentistry
A Medicine and Dentistry > A990 Medicine and Dentistry not elsewhere classified
Divisions:College of Social Science > Lincoln International Institute for Rural Health
College of Social Science > School of Health & Social Care
ID Code:51988
Deposited On:12 Oct 2022 14:05

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