Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia

Aloysius, Mark M., Zaitoun, Abed M., Bates, Timothy E. , Albasri, Abdulkader, Ilyas, Mohammad, Rowlands, Brian J. and Lobo, Dileep N. (2009) Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia. BMC cancer, 9 . p. 327. ISSN 1471-2407

Full content URL: http://www.biomedcentral.com/1471-2407/9/327

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Item Type:Article
Item Status:Live Archive

Abstract

Elevated serum concentrations of M2-pyruvate kinase (M2-PK) correlate with poor prognosis in patients with pancreaticobiliary and duodenal cancer, but the expression of M2-PK in formalin-fixed pancreatic tissue is unknown. We aimed to characterise the immunohistochemical expression of M2-PK in archived specimens of pancreaticobiliary and duodenal cancers, premalignant lesions, chronic pancreatitis, and normal pancreas.

Keywords:M2-pyruvate kinase, pancreatic cancer, duodenal neoplasia, epithelium neoplasia, immunohistochemistry
Subjects:A Medicine and Dentistry > A300 Clinical Medicine
B Subjects allied to Medicine > B130 Pathology
Divisions:College of Science > School of Life Sciences
ID Code:5192
Deposited On:25 Jun 2012 21:46

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