Protein-based nanomaterials: a new tool for targeted drug delivery.

Aljabali, Alaa Aa, Rezigue, Meriem, Alsharedeh, Rawan H , Obeid, Mohammad A, Mishra, Vijay, Serrano-Aroca, Ángel, El-Tanani, Mohamed and Tambuwala, Murtaza (2022) Protein-based nanomaterials: a new tool for targeted drug delivery. Therapeutic delivery, 13 (6). pp. 321-338. ISSN 2041-5990

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Protein-based nanomaterials: a new tool for targeted drug delivery.
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Protein nanomaterials are well-defined, hollow protein nanoparticles comprised of virus capsids, virus-like particles, ferritin, heat shock proteins, chaperonins and many more. Protein-based nanomaterials are formed by the self-assembly of protein subunits and have numerous desired properties as drug-delivery vehicles, including being optimally sized for endocytosis, nontoxic, biocompatible, biodegradable and functionalized at three separate interfaces (external, internal and intersubunit). As a result, protein nanomaterials have been intensively investigated as functional entities in bionanotechnology, including drug delivery, nanoreactors and templates for organic and inorganic nanomaterials. Several variables influence efficient administration, particularly active targeting, cellular uptake, the kinetics of the release and systemic elimination. This review examines the wide range of medicines, loading/release processes, targeted therapies and treatment effectiveness.

Keywords:capsid proteins; nanotechnology; protein-based nanoparticles; targeted drug delivery; viruses
Subjects:H Engineering > H812 Pharmaceutical Engineering
A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > Lincoln Medical School
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ID Code:51714
Deposited On:27 Sep 2022 13:41

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