Detection of a Novel Y-Chromosome Allele Variant for Locus DYS518

Giangasparo, Federica, Iyavoo, Sasitaran, Haizel, Thomas , Devesse, Laurence Alicia, Ballard, David and Court, Denise Syndercombe (2022) Detection of a Novel Y-Chromosome Allele Variant for Locus DYS518. Forensic Genomics, 2 (2). pp. 38-41. ISSN 2690-8956

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A rare allele 22 at marker DYS518 was detected during a wider population study of Y-chromosome short tandem repeat (STR) loci. The novel variant was discovered using the YFiler® Plus PCR Amplification kit and the sequence of the new allele confirmed with Sanger sequencing. The allele range for marker DYS518 in the included ladder in the amplification kit falls between alleles 32 and 49 with a minimum allele size of 332 bp. Variants outside this range have already been discovered and their frequency is available in the worldwide Y-chromosome STR Haplotype Reference Database (YHRD) containing >250,000 STR haplotypes. Nonetheless, the rare allele described in this study has not been seen among the YHRD data set samples, which has recorded alleles between 28 and 52.2, nor in other population studies published to date.

Keywords:Y-STR, DYS518, rare Y allele, Yfiler Plus
Subjects:F Physical Sciences > F410 Forensic Science
Divisions:College of Science > School of Chemistry
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ID Code:49964
Deposited On:12 Sep 2022 10:27

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