Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

Yan, Li, Li, Juan, Gopal, Ashna , Roberts, Samuel C., Lin, Jia-fu, Liu, Ting-ting, Munshi, Tasnim, Zhang, Xiujuan and Chen, Xianfeng (2022) Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria. Materials Today Communication, 30 (103101). pp. 1-7. ISSN 2352-4928

Full content URL: https://doi.org/10.1016/j.mtcomm.2021.103101

Documents
Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteri
Authors' Accepted Manuscript

Request a copy
[img] Microsoft Word
Revision Clean Version.docx - Whole Document
Restricted to Repository staff only until 21 December 2022.

3MB
Item Type:Article
Item Status:Live Archive

Abstract

Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.

Keywords:Antibiotics, Bacterial Resistance, layered double hydroxides
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
Related URLs:
ID Code:47825
Deposited On:26 Jan 2022 15:03

Repository Staff Only: item control page