Yan, Li, Li, Juan, Gopal, Ashna , Roberts, Samuel C., Lin, Jia-fu, Liu, Ting-ting, Munshi, Tasnim, Zhang, Xiujuan and Chen, Xianfeng (2022) Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria. Materials Today Communication, 30 (103101). pp. 1-7. ISSN 2352-4928
Full content URL: https://doi.org/10.1016/j.mtcomm.2021.103101
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Item Type: | Article |
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Item Status: | Live Archive |
Abstract
Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.
Keywords: | Antibiotics, Bacterial Resistance, layered double hydroxides |
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Subjects: | F Physical Sciences > F100 Chemistry |
Divisions: | College of Science > School of Chemistry |
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ID Code: | 47825 |
Deposited On: | 26 Jan 2022 15:03 |
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