Cell adhesion in renal tubular epithelial cells: Biochemistry, biophysics or both

Hills, Claire, Siamantouras, Eleftherios and Squires, Paul (2021) Cell adhesion in renal tubular epithelial cells: Biochemistry, biophysics or both. BIOCELL, 46 (4). pp. 937-940. ISSN 0327-9545

Full content URL: https://www.doi.org/10.32604/biocell.2022.018414

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Cell adhesion in renal tubular epithelial cells: Biochemistry, biophysics or both
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Abstract

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and progression. However, these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix, as well as the biophysical and mechanical properties orchestrated by cytoskeletal, membrane and matrix components. To fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function, it is important to consider both biochemical and biophysical attributes of the system being investigated. In this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

Keywords:cell adhesion, cadherin, cytoskeleton, Atomic force microscopy, AFM, kidney, epithelium
Subjects:A Medicine and Dentistry > A100 Pre-clinical Medicine
C Biological Sciences > C130 Cell Biology
B Subjects allied to Medicine > B120 Physiology
Divisions:College of Science > School of Life Sciences
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ID Code:47586
Deposited On:21 Dec 2021 14:43

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