Biomechanics of glutaraldehyde-treated porcine aortic roots and valves

Lockie, K.J., Fisher, J., Juster, N.P. , Davies, G.A. and Watterson, K. (1994) Biomechanics of glutaraldehyde-treated porcine aortic roots and valves. The Journal of Thoracic and Cardiovascular Surgery, 108 (6). pp. 1037-1042. ISSN 0022-5223

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The biomechanics and function of fresh porcine aortic roots and valves have been compared with those of glutaraldehyde-treated roots prepared in a conventional manner without dilation of the elastic aortic root and with glutaraldehyde-treated roots prepared with permanent predilation during fixation. The glutaraldehyde-treated aortic walls were significantly less extensible than fresh walls, with a mean dilation of only 6 % compared with 45% for the fresh root at 120 mm Hg pressure. Permanent predilation of the aortic root during fixation allowed the total dilation of the fixed root to be increased to 19% at 120 mm Hg pressure. The effective orifice area of the fresh root and valve was significantly greater than those of the fixed roots and valves, with permanent predilation fixation producing a significantly greater orifice area than conventional fixation. The open-leaflet bending deformations were found to be lower in the valves fixed after permanent predilation than in the standard fixed valves. The glutaraldehyde-treated porcine root and valve does not reproduce the biomechanics and function of the fresh root, because of the reduced extensibility of the fixed aortic wall. Permanent predilation during fixation helps to partially overcome the shortcomings of the fixed root, producing better function than a standard fixed valve.

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ID Code:47072
Deposited On:28 Oct 2021 13:30

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