Synthesis of Teixobactin Analogues and their Biological Evaluation

Parmar, Anish (2019) Synthesis of Teixobactin Analogues and their Biological Evaluation. PhD thesis, University of Lincoln.

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Synthesis of Teixobactin Analogues and their Biological Evaluation
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Parmar, Anish - Pharmacy - September 2019.pdf - Whole Document

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Item Type:Thesis (PhD)
Item Status:Live Archive

Abstract

The work herein is part of my PhD for four years (April 2015- October 2018) at Lincoln University, UK. I have had the opportunity to travel to Temple University, Philadelphia, the USA, to advance my techniques and work on other collaborated projects. Other projects have not been included in this thesis due to the relevancy of work and I had gained enough data on teixobactin to cover this entire thesis.

For convenience, I have split the descriptive and experimental sections and numbered tables, figures and references chapter-wise. Since all the work herein has been published by our group, me being the first author/co-joint first author, relevant texts have been directly taken from the articles and permissions have been granted from co-authors for the use of data.

The first chapter of the thesis covers - the introduction of bacteria, antibiotics, antimicrobial resistance and teixobactin. The later chapters focus on the efficient synthesis of the teixobactin analogue and the invention of more potent analogues, followed by the final overview of work from myself and others on teixobactin.

Please bear in mind, this thesis is a pinnacle of hard work, dedication and support not just by me and my supervisor but a range of collaborators from different research groups who have significantly contributed to the publications received. Happy reading!

Divisions:College of Science > School of Pharmacy
ID Code:46819
Deposited On:04 Oct 2021 14:06

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