Unconventional Myosins: How Regulation Meets Function.

Fili, Natalia and Toseland, Christopher P. (2019) Unconventional Myosins: How Regulation Meets Function. International Journal of Molecular Sciences, 21 (1). ISSN 1422-0067

Full content URL: https://doi.org/10.3390/ijms21010067

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Item Type:Article
Item Status:Live Archive


Unconventional myosins are multi-potent molecular motors that are assigned important roles in fundamental cellular processes. Depending on their mechano-enzymatic properties and structural features, myosins fulfil their roles by acting as cargo transporters along the actin cytoskeleton, molecular anchors or tension sensors. In order to perform such a wide range of roles and modes of action, myosins need to be under tight regulation in time and space. This is achieved at multiple levels through diverse regulatory mechanisms: the alternative splicing of various isoforms, the interaction with their binding partners, their phosphorylation, their applied load and the composition of their local environment, such as ions and lipids. This review summarizes our current knowledge of how unconventional myosins are regulated, how these regulatory mechanisms can adapt to the specific features of a myosin and how they can converge with each other in order to ensure the required tight control of their function.

Keywords:Myosins, Unconventional, Regulation
Subjects:C Biological Sciences > C130 Cell Biology
Divisions:College of Science > School of Life and Environmental Sciences > Department of Life Sciences
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ID Code:46357
Deposited On:06 Jan 2023 16:49

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