Large age shifts in HIV-1 incidence patterns in KwaZulu-Natal, South Africa

Akullian, Adam, Vandormael, Alain, Miller, Joel C. , Bershteyn, Anna, Wenger, Edward, Cuadros, Diego, Gareta, Dickman, Bärnighausen, Till, Herbst, Kobus and Tanser, Frank (2021) Large age shifts in HIV-1 incidence patterns in KwaZulu-Natal, South Africa. Proceedings of the National Academy of Sciences, 118 (28). e2013164118. ISSN 0027-8424

Full content URL: https://doi.org/10.1073/pnas.2013164118

Documents
Large age shifts in HIV-1 incidence patterns in KwaZulu-Natal, South Africa
Published Open Access manuscript
[img]
[Download]
[img]
Preview
PDF
e2013164118.full.pdf - Whole Document
Available under License Creative Commons Attribution 4.0 International.

1MB
Item Type:Article
Item Status:Live Archive

Abstract

HIV incidence has recently been in decline across some of the most intense epidemics in sub-Saharan Africa due to the scale-up of prevention and transmission-blocking treatments. Understanding whether declines in incidence are being felt equally across age and gender can help prioritize demographic groups where more effort is needed to lower transmission. We found that HIV incidence has declined disproportionately in the youngest men and women in a population with the highest HIV prevalence in the world. Shifts in the age distribution of risk may be the consequence of aging prevalence, prioritized prevention to younger individuals, and delays in age at infection from reduced overall force of infection. Our results highlight the need to expand age targets for HIV prevention.

Subjects:B Subjects allied to Medicine > B990 Subjects Allied to Medicine not elsewhere classified
Divisions:College of Social Science > Lincoln International Institute for Rural Health
ID Code:45816
Deposited On:19 Jul 2021 14:28

Repository Staff Only: item control page