Airborne Particulate Matter and SARS-CoV-2 Partnership: Virus Hitchhiking, Stabilization and Immune Cell Targeting—A Hypothesis

Farhangrazi, Z Shadi, Sancini, Giulio, Hunter, A Christy and Moghimi, Seyed Moein (2020) Airborne Particulate Matter and SARS-CoV-2 Partnership: Virus Hitchhiking, Stabilization and Immune Cell Targeting—A Hypothesis. Frontiers in Immunology, 11 . ISSN 1664-3224

Full content URL: https://doi.org/10.3389/fimmu.2020.579352

Full text not available from this repository.

Item Type:Article
Item Status:Live Archive

Abstract

It is widely assumed that the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in humans occurs through close contact with an infected person, short-range transmission through respirable droplets from an infected individuals' cough or sneeze, and aerosolized airborne droplets in long-range (over a few meters) transmission (1). Large respirable droplets (>5 μm) rapidly settle out of the air, whereas virus-laden small droplets (<5 μm), often referred to as “droplet nuclei” remain longer in the air and propagate depending on air-flow (1). Assuming that a fraction of aerosols remains infective, “droplet-nuclei” might contribute to airborne transmission of the virus, particularly in poorly ventilated and crowded indoor spaces. A recent commentary, and supported with >200 signatories, has further stressed the importance of inhalation exposure to viruses in respirable droplets at short to medium distances (up to several meters) (2).

In contrast to the inhalation mode of viral transmission through airborne respirable droplets, here we speculate an additional role for settled and airborne particulate matter (PM) not only in viral transmission through inhalation and ingestion, but also in promoting immunity through antigen delivery, adjuvanticity and trained immunity.

Keywords:alveolar macrophage, COVID-19, dendritic cell, immunity, particulate matter, pulmonary delivery, SARS-CoV-2, trained immunity
Subjects:C Biological Sciences > C550 Immunology
Divisions:College of Science > School of Pharmacy
ID Code:45552
Deposited On:29 Jun 2021 15:47

Repository Staff Only: item control page