Complement activation by PEG-functionalized multi-walled carbon nanotubes is independent of PEG molecular mass and surface density

Andersen, Alina J, Windschiegl, Barbara, Ilbasmis-Tamer, Sibel , Degim, Ismail T, Hunter, Alan Christy, Andresen, Thomas L and Moghimi, Seyed Moein (2013) Complement activation by PEG-functionalized multi-walled carbon nanotubes is independent of PEG molecular mass and surface density. Nanomedicine: Nanotechnology, Biology and Medicine, 9 (4). pp. 469-473. ISSN 1549-9634

Full content URL: https://doi.org/10.1016/j.nano.2013.01.011

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Item Type:Article
Item Status:Live Archive

Abstract

Carboxylated (4%) multi-walled carbon nanotubes were covalently functionalized with poly(ethylene glycol)1000 (PEG1000), PEG1500 and PEG4000 with a PEG loading of approximately 11% in all cases. PEG loading generated non-uniform and heterogeneous higher surface structures and increased nanotube width considerably, but all PEGylated nanotube species activated the complement system in human serum equally. Increased PEG loading, through adsorption of methoxyPEG2000(or 5000)-phospholipid conjugates, generated fewer complement activation products; however, complement activation was never completely eliminated. Our observations address the difficulty in making carbon nanotubes more compatible with innate immunity through covalent PEG functionalization as well as double PEGylation strategies.

Divisions:College of Science > School of Pharmacy
ID Code:45520
Deposited On:30 Jun 2021 08:59

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