The microbiological hydroxylation of 3, 16-disubstituted androstanes by Cephalosporium aphidicola

Hanson, James R, Hitchcock, Peter B and Hunter, A Christy (1998) The microbiological hydroxylation of 3, 16-disubstituted androstanes by Cephalosporium aphidicola. Phytochemistry, 49 (5). pp. 1287-1292. ISSN 0031-9422

Full content URL: https://doi.org/10.1016/S0031-9422(98)00096-X

Full text not available from this repository.

Item Type:Article
Item Status:Live Archive

Abstract

5α-Androstane-3, 16-dione has been prepared by hydroboration and oxidation of 3β-hydroxy-5α-androst-16-ene. Reduction with sodium borohydride gave the 3β, 16β-diol. The fungus Cephalosporium aphidicola has been shown to hydroxylate 5α-androstane-3, 16-dione predominantly at the C-6β position with minor hydroxylation occurring at the C-7α and C-14α positions. In contrast hydroxylation of the 3β, 16β-diol took place at C-11α. The 3β-hydroxy-16α, 17α-epoxide was hydroxylated at the C-6β position.

Keywords:Cephalosporium aphidicola, microbiological hydroxylation, steroid, 5?-androstane-3, 16-dione
Divisions:College of Science > School of Pharmacy
ID Code:45489
Deposited On:13 Jul 2021 12:06

Repository Staff Only: item control page