Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective

Hunter, A Christy, Elsom, Jacqueline, Wibroe, Peter P and Moghimi, S Moein (2012) Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective. Maturitas, 73 (1). pp. 5-18. ISSN 0378-5122

Full content URL: https://doi.org/10.1016/j.maturitas.2012.05.014

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Item Type:Article
Item Status:Live Archive

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

Keywords:Oral drug delivery, Polymer, Gastrointestinal tract, Nanoparticle, Microparticle, Peyers's patch, Enterocyte, Complement
Divisions:College of Science > School of Pharmacy
ID Code:45461
Deposited On:13 Jul 2021 12:17

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