Cationic carriers of genetic material and cell death: a mitochondrial tale

Hunter, A Christy and Moghimi, S Moein (2010) Cationic carriers of genetic material and cell death: a mitochondrial tale. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1797 (6-7). pp. 1203-1209. ISSN 0005-2728

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Central to gene therapy technology has been the use of cationic polymers as vectors for DNA and RNA (polyfectins). These have been presumed to be safer than viral systems which, for example, have been found to switch on oncogenes. Two key polycations that have been intensively researched for use as synthetic vectors are poly(ethylenimine) and poly(l-lysine). A frequent stumbling block with these polyfectins is that long-term gene expression in cell lines has not been achieved. Recently it has transpired that both of these polycations can induce mitochondrially mediated apoptosis. It is the aim of this review to discuss the mechanisms behind the observed polycation toxicity including roles for little studied cellular organelles in the process such as the lysosome and endoplasmic reticulum.

Keywords:Mitochondria, Polycation, Apoptosis, Lysosome, Endolysosomotrophic agent, Gene therapy, Poly(ethylenimine), Poly(l-lysine), Bid, Gene transfection, Surfactant
Divisions:College of Science > School of Pharmacy
ID Code:45413
Deposited On:21 Jul 2021 14:58

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