Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment

Kocoglu, Koray, Hodgson, Timothy, Boz, Hatice Eraslan and Akdal, Gulden (2021) Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 43 (2). ISSN 1744-411

Full content URL: https://doi.org/10.1080/13803395.2021.1900077

Documents
Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment.pdf

Request a copy
Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment
Authors' Accepted Manuscript

Request a copy
[img] PDF
Deficits in saccadic eye movements differ between subtypes of patients with mild cognitive impairment.pdf
Restricted to Repository staff only

2MB
[img] Microsoft Word
Manuscript MCI accepted.docx - Whole Document
Restricted to Repository staff only until 1 April 2022.

80kB
Item Type:Article
Item Status:Live Archive

Abstract

Introduction: Mild cognitive impairment (MCI) is known to be heterogeneous in its cognitive features and course of progression. Whilst memory impairment is characteristic of amnestic MCI (aMCI), cognitive deficits other than memory can occur in both aMCI and non-amnestic MCI (naMCI) and accurate assessment of the subtypes of MCI is difficult for clinicians without the application of extensive neuropsychological testing. In this study, we examine metrics derived from recording of reflexive and voluntary saccadic eye movements as a potential alternative method for discriminating between subtypes and assessing cognitive functions in MCI.
Method: A total of 29 MCI patients and 29 age- and education-matched healthy controls (HCs) participated in the cross-sectional study. We recorded horizontal and vertical pro-saccades and anti-saccade responses. All the participants also completed a comprehensive neuropsychological tests battery.
Results: Significant differences in saccadic eye movement were found between the subtypes of MCI and HCs. Patients with aMCI had a higher percentage of short latency “express” saccades than HCs. We found strong associations between saccadic reaction times and cognitive domains, including executive functions and attention. The mini-mental state examination (MMSE) was also found to correlate with uncorrected errors in the anti-saccade task.
Conclusions: The increased proportion of saccades in the express latency range in aMCI may be indicative of problems with cognitive inhibitory control in these patients. A focus on this and other saccade metrics in the preclinical and prodromal stages of dementia may help to predict the clinical progression of the disease and direct interventions for the management of MCI. The clinical significance of saccadic eye movement impairments in MCI is not yet fully understood and should be investigated in further studies using larger samples.

Keywords:Mild cognitive impairment, cognition, executive function, eye movements, saccades
Subjects:C Biological Sciences > C860 Neuropsychology
Divisions:College of Social Science > School of Psychology
ID Code:44467
Deposited On:13 May 2021 15:02

Repository Staff Only: item control page