Patients’ experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research

Laparidou, Despina, Curtis, Ffion, Akanuwe, Joseph , Jackson, Jennifer, Hodgson, Timothy and Siriwardena, A. Niroshan (2021) Patients’ experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research. PLOS ONE, 16 (2). e0245826. ISSN 1932-6203

Full content URL: https://doi.org/10.1371/journal.pone.0245826

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Patients’ experiences and perceptions of Guillain-Barre´ syndrome: A systematic review and meta-synthesis of qualitative research
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Abstract

Background
Guillain-Barre´ syndrome (GBS) is an immune-mediated polyradiculoneuropathy, with an incidence of 1-2/100,000 per year. Its severity is variable, ranging from very mild cases with brief weakness to severe paralysis, leading to inability to breathe independently, or even death. Currently there is limited evidence exploring the experiences of GBS patients. The aim of this study was to review patients’ experiences and perceptions of GBS and its variants at diagnosis, discharge and during recovery, by conducting a systematic review and thematic meta-synthesis of qualitative studies of patients’ experiences of GBS (and its variants).
Methods
We searched twelve electronic databases, supplemented with internet searches and forward and backward citation tracking from the included studies and review articles. Data were synthesised thematically following the Thomas and Harden approach. The CASP Qualitative Checklist was used to assess the quality of the included studies of this review.
Results
Our search strategy identified a total of 5,282 citations and after removing duplicates and excluding citations based on title and abstract, and full-text screening, five studies were included in the review and meta-synthesis; all included studies were considered of acceptable quality. Through constant discussions and an iterative approach, we developed six analytical themes following a patient’s journey from suspecting that they had a health problem,
through to being hospitalised, experiencing ongoing difficulties, slowly recovering from GBS, adjusting to their new circumstances, and re-evaluating their lives.
Conclusions
Despite the variety of experiences, it was evident from all included studies that being diagnosed with and surviving GBS was a life-changing experience for all participants.
Trial registration
Protocol was registered (CRD42019122199) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO).

Keywords:Guillain-Barré Syndrome, Patient experiences, systematic review, metasynthesis
Subjects:B Subjects allied to Medicine > B740 Adult Nursing
B Subjects allied to Medicine > B771 Critical Care Nursing
B Subjects allied to Medicine > B710 Community Nursing
B Subjects allied to Medicine > B920 Occupational Health
A Medicine and Dentistry > A300 Clinical Medicine
Divisions:College of Social Science > School of Health & Social Care
ID Code:43978
Deposited On:23 Feb 2021 12:54

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