Comparative evolutionary genetics of deleterious load in sorghum and maize

Lozano, Roberto, Gazave, Elodie, dos Santos, Jhonathan P. R. , Stetter, Markus G., Valluru, Ravi, Bandillo, Nonoy, Fernandes, Samuel B., Brown, Patrick J., Shakoor, Nadia, Mockler, Todd C., Cooper, Elizabeth A., Perkins, M. Taylor, Buckler, Edward S., Ross-Ibarra, Jeffrey and Gore, Michael A. (2021) Comparative evolutionary genetics of deleterious load in sorghum and maize. Nature Plants, 7 (1). pp. 17-24. ISSN 2055-0278

Full content URL: https://doi.org/10.1038/s41477-020-00834-5

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Comparative evolutionary genetics of deleterious load in sorghum and maize
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Abstract

Sorghum and maize share a close evolutionary history that can be explored through comparative genomics1,2. To perform a large-scale comparison of the genomic variation between these two species, we analysed ~13 million variants identi- fied from whole-genome resequencing of 499 sorghum lines together with 25 million variants previously identified in 1,218 maize lines. Deleterious mutations in both species were prev- alent in pericentromeric regions, enriched in non-syntenic genes and present at low allele frequencies. A comparison of deleterious burden between sorghum and maize revealed that sorghum, in contrast to maize, departed from the domestication-cost hypothesis that predicts a higher deleterious burden among domesticates compared with wild lines. Additionally, sorghum and maize population genetic summary statistics were used to predict a gene deleterious index with an accuracy greater than 0.5. This research represents a key step towards understanding the evolutionary dynamics of deleterious variants in sorghum and provides a comparative genomics framework to start prioritizing these variants for removal through genome editing and breeding.

Keywords:Deleterious mutations, genetic load, sorghum, maize
Subjects:C Biological Sciences > C400 Genetics
Divisions:College of Science > Lincoln Institute for Agri-Food Technology
ID Code:43715
Deposited On:16 Feb 2021 11:33

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