Anti-retroviral therapy and incidence of adverse drug reactions among cohort of Malaysian HIV/AIDs patients

Ahmed, Syed Imran, Sulaiman, Syed Azhar Syed, Hassali, Mohamed Azmi , Shan, Lau Hui, Hasan, Syed Shazhad and Lee, Christopher KC (2014) Anti-retroviral therapy and incidence of adverse drug reactions among cohort of Malaysian HIV/AIDs patients. HealthMED, 8 (9). pp. 1031-1039. ISSN 1840-2291

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Background: Adverse drug reactions (ADRs) affect patients’ compliance and health related quality of life. HIV patients face challenges in adherence to their medications and experience side effects affecting their overall well-being, a primary outcome of HIV/AIDS treatment.

Methods: Four hundred and forty three Malaysians with a known diagnosis of HIV/AIDS, using Antiretroviral Therapy (ART) for at least past three months, were invited to participate in this study. The data were analyzed using the Statistical Package for Social Sciences (SPSS®) version 18 and STATA IC® version 12.

Results: About 44% (n=194) of total 443 HIV patients reported ADR, among them 131 (67.5%) were male while 63 (32.4 %) were females. Weight loss (12.6%), lipodystrophy (12.4%), peripheral neuropathy (12%), itchiness (11.7%) and skin problems (8.6%) were frequently found ADRs. Almost similar numbers of patients experienced ADRs who were combivir based (21.7%) and other drug therapy (22.1%) and this translated insignificant association between type of therapy and ADRs. However the poor CD4 counts (OR 1.72, 95% CI: 1.04 — 2.86), and poor viral suppression (OR 1.87, 95% CI: 1.04 — 3.36) did increase the odds of experiencing adverse drug reactions.

Conclusion: Uninformed and unpredictable ADRs may lead to non-adherence, poor health related quality of life and refusal to take medications which can ultimately affect the outcomes of HIV program. This poses a great necessity for optimizing pharmacovigilance services by addressing areas that require more attention.

Keywords:HIV & AIDS, Adverse Drug Reactions, anti-retroviral therapy
Subjects:B Subjects allied to Medicine > B230 Pharmacy
Divisions:College of Science > School of Pharmacy
ID Code:43062
Deposited On:18 Nov 2020 13:08

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