Autoimmunity to tetraspanin-7 in type 1 diabetes

McLaughlin, Kerry A, Tombs, Melissa and Christie, Michael (2020) Autoimmunity to tetraspanin-7 in type 1 diabetes. Medical Microbiology and immunology . ISSN 0300-8584

Full content URL:

Autoimmunity to tetraspanin-7 in type 1 diabetes
Published Open Access journal
McLaughlin_et_al-2020-Medical_Microbiology_and_Immunology.pdf - Whole Document
Available under License Creative Commons Attribution 4.0 International.

Item Type:Article
Item Status:Live Archive


Type 1 diabetes is an autoimmune disease whereby components of insulin-secreting pancreatic beta cells are targeted by the adaptive immune system leading to the destruction of these cells and insulin deficiency. There is much interest in the development of antigen-specific immune intervention as an approach to prevent disease development in individuals identified as being at risk of disease. It is now recognised that there are multiple targets of the autoimmune response in type 1 diabetes, the most recently identified being a member of the tetraspanin family, tetraspanin-7. The heterogeneity of autoimmune responses to different target antigens complicates the assessment of diabetes risk by the detection of autoantibodies, as well as creating challenges for the design of strategies to intervene in the immune response to these autoantigens. This review describes the discovery of tetraspanin-7 as a target of autoantibodies in type 1 diabetes and how the detection of autoantibodies to the protein provides a valuable marker for future loss of pancreatic beta-cell function.

Keywords:type 1 diabetes, Autoimmunity, Autoantibodies, Disease prediction
Subjects:C Biological Sciences > C550 Immunology
A Medicine and Dentistry > A100 Pre-clinical Medicine
Divisions:College of Science > School of Life Sciences
Related URLs:
ID Code:40988
Deposited On:16 Jun 2020 13:17

Repository Staff Only: item control page