Foster, Jamie S., Żurek, Justyna M., Almeida, Nuno M. S. , Hendriksen, Wouter E., le Sage, Vincent A. A., Lakshminarayanan, Vasudevan, Thompson, Amber L., Banerjee, Rahul, Eelkema, Rienk, Mulvana, Helen, Paterson, Martin J., van Esch, Jan H. and Lloyd, Gareth O. (2015) Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System. Journal of the American Chemical Society, 137 (45). pp. 14236-14239. ISSN 0002-7863
Full content URL: https://doi.org/10.1021/jacs.5b06988
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JACS Lloyd 2015_pdf.pdf - Whole Document Available under License Creative Commons Attribution-NoDerivatives 4.0 International. 1MB |
| Item Type: | Article |
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| Item Status: | Live Archive |
Abstract
Simultaneous control of the kinetics and
thermodynamics of two different types of covalent
chemistry allows pathway selectivity in the formation of
hydrogelating molecules from a complex reaction network.
This can lead to a range of hydrogel materials with vastly
different properties, starting from a set of simple starting
compounds and reaction conditions. Chemical reaction
between a trialdehyde and the tuberculosis drug isoniazid
can form one, two, or three hydrazone connectivity
products, meaning kinetic gelation pathways can be
addressed. Simultaneously, thermodynamics control the
formation of either a keto or an enol tautomer of the
products, again resulting in vastly different materials.
Overall, this shows that careful navigation of a reaction
landscape using both kinetic and thermodynamic
selectivity can be used to control material selection from
a complex reaction network.
| Keywords: | supramolecular hydrogel, pathway complexity, chemical landscape |
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| Subjects: | F Physical Sciences > F100 Chemistry |
| Divisions: | College of Science > School of Chemistry |
| ID Code: | 38117 |
| Deposited On: | 09 Apr 2020 10:10 |
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