Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy

Ramalhete, Susana M., Nartowski, Karol P., Sarathchandra, Nichola , Foster, Jamie S., Round, Andrew N., Angulo, Jesús, Lloyd, Gareth O. and Khimyak, Yaroslav Z. (2017) Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy. Chemistry - A European Journal, 23 (33). pp. 8014-8024. ISSN 0947-6539

Full content URL: https://doi.org/10.1002/chem.201700793

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Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy
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Abstract

Supramolecular hydrogels are composed of self-assembled solid networks that restrict the flow of water. l-Phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi-component hydrogels of l-phenylalanine are used herein as model materials to develop an NMR-based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid-state NMR experiments and microscopic techniques. Solution-state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using high-resolution magic angle spinning (HR-MAS) and saturation transfer difference (STD) NMR experiments. This approach allowed the identification of which additive molecules contributed in modifying the material properties.

Keywords:Hydrogels, Nuclear magnetic resonance spectroscopy, Gels, Amino Acids, Phenylalanine, Magic angle spinning, saturation transfer difference NMR
Subjects:F Physical Sciences > F100 Chemistry
Divisions:College of Science > School of Chemistry
ID Code:38102
Deposited On:15 Apr 2020 09:34

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