Post-transcriptional regulation of gene expression by Unr

Ray, Swagat, Catnaigh, Pol and Anderson, Emma C. (2015) Post-transcriptional regulation of gene expression by Unr. Biochemical Society Transactions, 43 (3). ISSN 0300-5127

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Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can vary with cell type and changing cellular conditions. Recent high-throughput analyses of RNA-protein interactions indicate that Unr binds to a large subset of cellular mRNAs, suggesting that Unr may play a wider role in translational responses to cellular signals than previously thought.

Keywords:Apoptosis,Internal ribosome entry site,Messenger RNA (mRNA) stability,Mitosis,Translation initiation,Upstream of N-ras (Unr)
Subjects:C Biological Sciences > C130 Cell Biology
Divisions:College of Science > School of Life Sciences
ID Code:37146
Deposited On:27 Sep 2019 10:21

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